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Review
. 2023 Feb 6;30(2):1954-1976.
doi: 10.3390/curroncol30020152.

Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction

Ali A Rabaan  1   2   3 , Hajir AlSaihati  4 , Rehab Bukhamsin  5 , Muhammed A Bakhrebah  6 , Majed S Nassar  6 , Abdulmonem A Alsaleh  7 , Yousef N Alhashem  7 , Ammar Y Bukhamseen  8 , Khalil Al-Ruhimy  9 , Mohammed Alotaibi  9 , Roua A Alsubki  10 , Hejji E Alahmed  11 , Saleh Al-Abdulhadi  12   13 , Fatemah A Alhashem  14 , Ahlam A Alqatari  15 , Ahmed Alsayyah  16 , Ramadan Abdelmoez Farahat  17 , Rwaa H Abdulal  18   19 , Ali H Al-Ahmed  20 , Mohd Imran  21 , Ranjan K Mohapatra  22
Affiliations
Review

Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction

Ali A Rabaan et al. Curr Oncol. .

Abstract

Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing's rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.

Keywords: CRISPR/Cas; advanced technologies; advanced therapeutics; cancer; cancer treatment; clinical trials; oncoviruses.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Operational scheme of CRISPR-Cas9.
Figure 2
Figure 2
CRISPR/Cas genome editing tool in the age of cancer treatment.
Figure 3
Figure 3
The presentations of the CRISPR/Cas system in multiple features of malignancy treatment.
See this image and copyright information in PMC

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