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. 2023 Jun;46(6):748-757.
doi: 10.1007/s00270-023-03385-2. Epub 2023 Feb 24.

A Retrospective Comparison of the Efficacy of Embolization with Imipenem/Cilastatin and Microspheres in the Management of Chronic Shoulder Pain

Mathieu Finas  1   2 , Julien Frandon  3 , Emeric Gremen  1   2 , Clément Horteur  1   4 , Michaël Benassayag  5 , Gabriel Lateur  6 , Régis Pailhe  1   4 , Gilbert Ferretti  1   2 , Alexandre Bellier  1   7 , Julien Ghelfi  8   9   10
Affiliations

A Retrospective Comparison of the Efficacy of Embolization with Imipenem/Cilastatin and Microspheres in the Management of Chronic Shoulder Pain

Mathieu Finas et al. Cardiovasc Intervent Radiol. 2023 Jun.

Abstract

Purpose: To compare the efficacy of embolization with imipenem/cilastatin and microspheres in chronic shoulder pain.

Methods: This retrospective study included 29 patients who underwent embolization for chronic shoulder pain between June 2017 and March 2022 with calibrated MSs from 100 to 250 µm or IMP/CS. The main objective was the clinical success evaluated by the Minimum Clinically Important Difference (MCID) at 3 months after the procedure, validated if the patient responded yes to 2 questions: (1) Is the pain less severe than before the procedure? (2) Are you satisfied with the procedure? The decrease in visual analogue pain scale scores and the safety of the procedure were evaluated.

Results: Embolization was achieved in all patients. In the MS group, 4/15 patients (26.7%) experienced clinical success at 3 months according to MCID versus 10/14 patients (71.4%) in the IMP/CS group (p = 0.02). The mean VAS decreases were respectively - 28.6% ± 34.6 in the MS group and - 36.8% ± 27.8 in the IMP/CS group at 1 month (p = 0.50), - 29.9% ± 29.0 and - 39.6% ± 23.0 at 3 months (p = 0.33) and - 30.6% ± 32.8 and - 46.6% ± 28.4 at 6 months after the procedure (p = 0.26). Eleven patients (73.3%) in the MS group and 3 patients (21.4%) in the IMP/CS group had complications (p = 0.01). Among them, 2/15 patients (13.3%) had transient skin ischaemia in the MS group.

Conclusion: Embolization with IMP/CS may be more effective and safer than MSs in the management of chronic shoulder pain.

Keywords: Chronic shoulder pain; Cilastatin; Embolization; Imipenem; Neovessels; Safety.

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References

    1. Tashjian RZ. Epidemiology, natural history, and indications for treatment of rotator cuff tears. Clin Sports Med. 2012;31(4):589–604. - DOI - PubMed
    1. Le HV, Lee SJ, Nazarian A, Rodriguez EK. Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments. Shoulder Elbow. 2017;9(2):75–84. - DOI - PubMed
    1. Garving C, Jakob S, Bauer I, Nadjar R, Brunner UH. Impingement syndrome of the shoulder. Dtsch Arztebl Int. 2017;114(45):765–76. - PubMed - PMC
    1. Shaffer B, Tibone JE, Kerlan RK. Frozen shoulder. A long-term follow-up. J Bone Joint Surg Am. 1992;74(5):738–46. - DOI - PubMed
    1. Okuno Y, Iwamoto W, Matsumura N, Oguro S, Yasumoto T, Kaneko T, et al. Clinical outcomes of transcatheter arterial embolization for adhesive capsulitis resistant to conservative treatment. J Vasc Interv Radiol févr. 2017;28(2):161-167.e1. - DOI

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