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. 2023 Mar;44(2):139-148.
doi: 10.1007/s00292-023-01183-8. Epub 2023 Feb 24.

[New WHO classification 2022: urinary bladder cancer]

[Article in German]
Nadine Therese Gaisa  1 , Arndt Hartmann  2 , Ruth Knüchel-Clarke  3
Affiliations

[New WHO classification 2022: urinary bladder cancer]

[Article in German]
Nadine Therese Gaisa et al. Pathologie (Heidelb). 2023 Mar.

Abstract
in English, German

The new World Health Organization (WHO) classification of urogenital tumors is still primarily based on anatomic location, but is also a hierarchical taxonomic classification without separate chapters for tumors of the upper urinary tract and the urethra. It clarifies aspects regarding grading and noninvasive entities. It consolidates the use of the Paris system for urinary cytology as well as various subtypes/special types of neoplasms, and incorporates general concepts of the 5th edition of the WHO blue book. In addition to mesenchymal tumors, well-differentiated neuroendocrine tumors and neuroendocrine carcinomas are addressed in separate chapters. Papillary non-invasive low- and high-grade carcinomas and carcinoma in situ remain, while dysplasia and urothelial proliferation of unknown malignant potential (UPUMP) are no longer treated as separate entities. Former variants of urothelial carcinoma are now called subtypes and aberrant differentiation and special types are more precisely defined.

Die neue WHO-Klassifikation der Tumoren der ableitenden Harnwege bleibt anatomisch unterteilt, ist aber auch eine hierarchisch taxonomische Klassifikation ohne separate Kapitel für die Tumoren der oberen Harnwege und der Urethra. Sie beleuchtet Aspekte des Gradings und der nichtinvasiven Entitäten, konsolidiert die Anwendung des Paris-Systems der Urinzytologie sowie die Sonderformen der Karzinome und setzt die Konzeptionsaspekte der 5. Auflage des WHO Blue Book um. Neben den mesenchymalen Tumoren werden die gut differenzierten neuroendokrinen Tumoren und neuroendokrinen Karzinome separat organübergreifend abgehandelt. Papilläre nichtinvasive „low-“ und „high-grade“ Karzinome sowie das Carcinoma in situ bleiben bestehen, während die Dysplasie und die „urothelial proliferation of unknown malignant potential“ (UPUMP) als eigenständige Entitäten nicht weitergeführt werden. Die Varianten des Urothelkarzinoms werden als Subtypen präziser beschrieben, die aberranten Differenzierungen und Sonderformen genauer definiert.

Keywords: Carcinoma in situ; Cytology; Molecular pathology; Neuroendocrine tumors; Urinary tract.

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