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Review
. 2023 Jan 29;21(2):98.
doi: 10.3390/md21020098.

Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance

Dioni Arrieche  1 , Jaime R Cabrera-Pardo  2 , Aurelio San-Martin  3 , Héctor Carrasco  4 , Lautaro Taborga  1
Affiliations
Review

Natural Products from Chilean and Antarctic Marine Fungi and Their Biomedical Relevance

Dioni Arrieche et al. Mar Drugs. .

Abstract

Fungi are a prolific source of bioactive molecules. During the past few decades, many bioactive natural products have been isolated from marine fungi. Chile is a country with 6435 Km of coastline along the Pacific Ocean and houses a unique fungal biodiversity. This review summarizes the field of fungal natural products isolated from Antarctic and Chilean marine environments and their biological activities.

Keywords: Chilean marine fungi; biological activities; marine fungi; marine natural products.

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Conflict of interest statement

The authors declare that they have no conflicting interest in the publication.

Figures

Figure 1
Figure 1
Secondary metabolites isolated from Cladosporium cladosporioides.
Figure 2
Figure 2
Secondary metabolites isolated from Penicillium brevicompactun.
Figure 3
Figure 3
Secondary metabolites isolated from Geotrichum sp.
Figure 4
Figure 4
Secondary metabolite isolated from Cladosporium cladosorioides.
Figure 5
Figure 5
Secondary metabolites isolated from Aspergillus sp.
Figure 6
Figure 6
Secondary metabolites isolated from Geomyces sp.
Scheme 1
Scheme 1
Proposed biosynthetic pathway to 26 and 27.
Scheme 2
Scheme 2
Biomimetic synthesis of ent-Penilactone A and Penilactone B.
Figure 7
Figure 7
Secondary metabolites isolated from Tridocherma asperellum.
Figure 8
Figure 8
Secondary metabolites isolated from Penicillium crustosum PRB-2.
Figure 9
Figure 9
Secondary metabolites isolated from the Antarctic fungus Oidiodendron truncatum.
Figure 10
Figure 10
Secondary metabolites isolated from Pseudogymnoascus sp.
Figure 11
Figure 11
Secondary metabolites isolated from Penicillium sp. S-1-18.
Figure 12
Figure 12
Penixylarins A–D, isolated from Penicillium crestosum PRB-2 and the fungus Xylaria sp. HDN12-249.
Figure 13
Figure 13
Secondary metabolites isolated from Penicillium chrysogenum.
Figure 14
Figure 14
Alkaloids isolated from Penicillium echinulatum.
Figure 15
Figure 15
Penicillic acid isolated from Penicillium sp. CRM-1540.
Figure 16
Figure 16
Talaverrucin A isolated from Penicillium sp. CRM-1540.
Figure 17
Figure 17
Citromycin isolated from Sporothrix sp.
Figure 18
Figure 18
Insucolides (D–G) isolated from Aspergillus insulicola HDN151418.
Figure 19
Figure 19
Perylenequinones isolated from Aspergillus insulicola HDN151418.
See this image and copyright information in PMC

References

    1. Tong Y., Deng Z. An Aurora of Natural Products-Based Drug Discovery Is Coming. Synth. Syst. Biotechnol. 2020;5:92–96. doi: 10.1016/j.synbio.2020.05.003. - DOI - PMC - PubMed
    1. Newman D.J., Cragg G.M. Natural Products as Sources of New Drugs from 1981 to 2014. J. Nat. Prod. 2016;79:629–661. doi: 10.1021/acs.jnatprod.5b01055. - DOI - PubMed
    1. Newman D.J., Cragg G.M. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. J. Nat. Prod. 2020;83:770–803. doi: 10.1021/acs.jnatprod.9b01285. - DOI - PubMed
    1. Clardy J., Walsh C. Lessons from Natural Molecules. Nature. 2004;432:829–837. doi: 10.1038/nature03194. - DOI - PubMed
    1. Choi J., Kim S.-H. A Genome Tree of Life for the Fungi Kingdom. Proc. Natl. Acad. Sci. USA. 2017;114:9391–9396. doi: 10.1073/pnas.1711939114. - DOI - PMC - PubMed

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