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. 2023 Jan 28;8(2):88.
doi: 10.3390/tropicalmed8020088.

Rationality of Prescriptions by Rational Use of Medicine Consensus Approach in Common Respiratory and Gastrointestinal Infections: An Outpatient Department Based Cross-Sectional Study from India

Debjit Chakraborty  1 , Falguni Debnath  1 , Suman Kanungo  1 , Sandip Mukhopadhyay  1 , Nabanita Chakraborty  1 , Rivu Basu  2 , Palash Das  3 , Kalpana Datta  4 , Suman Ganguly  5 , Prithwijit Banerjee  3 , Nilima Kshirsagar  6 , Shanta Dutta  1
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Rationality of Prescriptions by Rational Use of Medicine Consensus Approach in Common Respiratory and Gastrointestinal Infections: An Outpatient Department Based Cross-Sectional Study from India

Debjit Chakraborty et al. Trop Med Infect Dis. .

Abstract

Background: Drug utilisation studies are relevant for the analysis of prescription rationality and are pertinent in today's context of the increasing burden of antimicrobial resistance. Prescriptions for patients with diarrhoea or Acute Respiratory Infection (ARI) have been analysed in this study to understand the prescription pattern among various categories of prescribers in two tertiary care centers.

Methods: This cross-sectional study was conducted from August 2019 to December 2020 in the medicine and pediatrics outpatient departments of two government teaching hospitals in West Bengal, India. A total of 630 prescriptions were evaluated against WHO standards. Prescriptions were assessed by a 'Rational Use of Medicine Consensus committee' approach.

Results: The Fixed Dose Combination (FDC) was used in half of the patients (51%). Both the generic prescription (23.3%) and adherence to hospital formulary rates (36.5%) were low. The antibiotics prescription rate was high (57%), and it was higher for diarrhoea than ARI. Deviations from the standard treatment guidelines were found in 98.9% of prescriptions. Deviations were commonly found with prescriptions written by the junior doctors (99.6%).

Conclusion: Irrational prescribing patterns prevail in tertiary care centers and indicate the necessity of awareness generation and capacity building among prescribers regarding AMR and its unseen consequences.

Keywords: acute respiratory infection; antibiotics prescription rate; antimicrobial resistance; diarrhoea; prescription pattern; rational use of medicine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Acceptability of the deviations in assessed prescriptions through a consensus committee approach.
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References

    1. Promoting Rational Use of Medicines. [(accessed on 11 July 2022)]. Available online: https://www.who.int/activities/promoting-rational-use-of-medicines.
    1. Ofori-Asenso R., Agyeman A.A. Irrational Use of Medicines—A Summary of Key Concepts. Pharmacy. 2016;4:35. doi: 10.3390/pharmacy4040035. - DOI - PMC - PubMed
    1. Bigdeli M., Peters D.H., Wagner A.K. Medicines in Health Systems: Advancing Access, Affordability and Appropriate Use. World Health Organization; Geneva, Switzerland: 2014. [(accessed on 8 December 2022)]. Available online: https://apps.who.int/iris/handle/10665/179197.
    1. Holloway K.A. Combating inappropriate use of medicines. Expert Rev. Clin. Pharmacol. 2011;4:335–348. doi: 10.1586/ecp.11.14. - DOI - PubMed
    1. Sema F.D., Asres E.D., Wubeshet B.D. Evaluation of Rational Use of Medicine Using WHO/INRUD Core Drug Use Indicators at Teda and Azezo Health Centers, Gondar Town, Northwest Ethiopia. Integr. Pharm. Res. Pract. 2021;10:51–63. doi: 10.2147/IPRP.S316399. - DOI - PMC - PubMed

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