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Review
. 2023 Jan 31;12(2):341.
doi: 10.3390/antiox12020341.

Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations

Iman Ramli  1 , Anna Maria Posadino  2 , Roberta Giordo  3 , Grazia Fenu  2 , Manal Fardoun  4 , Rabah Iratni  5 , Ali H Eid  6 , Hatem Zayed  7 , Gianfranco Pintus  2
Affiliations
Review

Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations

Iman Ramli et al. Antioxidants (Basel). .

Abstract

Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts critical phases of the fetus's life and correlates to an increased risk of chronic pathological conditions, such as diabetes, obesity, and cardiovascular diseases, in both the mother's and adult offspring's life. The dietary intake of naturally occurring antioxidants promotes health benefits and disease prevention. In this regard, maternal dietary intake of polyphenolic antioxidants is linked to a reduced risk of maternal obesity and cardio-metabolic disorders, positively affecting both the fetus and offspring. In this work, we will gather and critically appraise the current literature highlighting the effect/s of the naturally occurring polyphenol antioxidant resveratrol on oxidative stress, inflammation, and other molecular and physiological phenomena associated with pregnancy and pregnancy conditions, such as gestational diabetes, preeclampsia, and preterm labor. The resveratrol impact on prenatal complications and pregnancy-associated structures, such as the fetus and placenta, will also be discussed. Finally, we will draw conclusions from the current knowledge and provide future perspectives on potentially exploiting resveratrol as a therapeutic tool in pregnancy-associated conditions.

Keywords: fetus; gestational diabetes; placenta; pre-eclampsia; pregnancy; prenatal; preterm; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Potential molecular mechanisms underpinning the effects of resveratrol intake in mothers and their offspring in different models.
Figure 2
Figure 2
Maternal resveratrol supplementation decreases the risk of adverse pregnancy outcomes by ameliorating the in-utero conditions. Schematic representation of the resveratrol-impacted crosstalk between abnormal in-utero conditions and adverse pregnancy risk.
See this image and copyright information in PMC

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