Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 19;12(2):521.
doi: 10.3390/antiox12020521.

The Impact of Whole-Body Cryotherapy on Endothelium Parameters in Patients with Ankylosing Spondylitis

Agata Stanek  1 , Ewa Romuk  2 , Tomasz Wielkoszyński  3 , Klaudia Brożyna-Tkaczyk  4 , Daria Wziątek-Kuczmik  5 , Armand Cholewka  6
Affiliations

The Impact of Whole-Body Cryotherapy on Endothelium Parameters in Patients with Ankylosing Spondylitis

Agata Stanek et al. Antioxidants (Basel). .

Abstract

Background: The aim of the study was to assess the effect of whole-body cryotherapy (WBC) with subsequent exercise training (WBC group) or exercise-only training (ET group) on endothelium inflammation parameters in patients with ankylosing spondylitis (AS).

Methods: The WBC procedure lasted 3 min, and exercise training consisted of one 60 min session a day, which was the same in each group. The ET group was compared to the WBC group. Endothelium (high-sensitivity C-reactive protein (hsCRP), soluble P-Selectin, soluble vascular cell adhesion molecule-1 (sVCAM-1), neopterin), and oxidative stress (lipid hydroperoxide (LHP), protein sulfhydryl (PSH), lipofuscin, paraoxonase-1(PON-1), and albumin) parameters were estimated 1 day before and 1 day after the completion of the study.

Results: A significant decrease in hsCRP, sP-Selectin, sVCAM-1, and neopterin concentrations was observed in the WBC group after the treatment. After the treatment, in both groups, LHP and lipofuscin levels and PON-1 activity decreased significantly. The observed drop in these parameters was higher in the WBC group compared to the ET group. Albumin concentration increased in the WBC group after treatment.

Conclusion: Procedures of WBC have a beneficial effect on endothelium parameters in AS patients; therefore, this method can be applied in the treatment of this group of patients.

Keywords: ankylosing spondylitis; endothelium parameters; oxidative stress; whole-body cryotherapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scheme of study protocol.
Figure 2
Figure 2
The mean percentage changes in endothelium function parameters in the WBC group (gray) and the ET group (black). The concentration of a given parameter at the first collection was assumed as 100%. Statistically significant differences between the first and second measurement (pre- and post-procedure) are marked as * and # in the WBC and ET groups, respectively (hsCRP: high-sensitivity C-reactive protein; sVCAM-1: soluble vascular cell adhesion molecule-1; (p): plasma; (s): serum).
Figure 3
Figure 3
The mean percentage change in oxidative stress parameters in the WBC group (gray) and the ET group (black). The concentration of a given parameter at the first collection was assumed as 100%. Statistically significant differences between the first and second measurement (pre- and post-procedure) are marked as * and # in the WBC and ET groups, respectively (LHP: lipid hydroperoxide; PON-1: paraoxonase-1; PSH: protein sulfhydryl; (e): erythrocyte lysates; (p): plasma; (s): serum).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Sieper J., Braun J., Rudwaleit M., Boonen A., Zink A. Ankylosing spondylitis: An overview. Ann. Rheum. Dis. 2002;61:iii8–iii18. doi: 10.1136/ard.61.suppl_3.iii8. - DOI - PMC - PubMed
    1. Zhu W., He X., Cheng K., Zhang L., Chen D., Wang X., Qiu G., Cao X., Weng X. Ankylosing spondylitis: Etiology, pathogenesis, and treatments. Bone Res. 2019;7:22. doi: 10.1038/s41413-019-0057-8. - DOI - PMC - PubMed
    1. van der Heijde D., Braun J., Deodhar A., Baraliakos X., Landewé R., Richards H.B., Porter B., Readie A. Modified stoke ankylosing spondylitis spinal score as an outcome measure to assess the impact of treatment on structural progression in ankylosing spondylitis. Rheumatology. 2019;58:388–400. doi: 10.1093/rheumatology/key128. - DOI - PMC - PubMed
    1. Braun J., Sieper J. Ankylosing spondylitis. Lancet. 2007;369:1379–1390. doi: 10.1016/S0140-6736(07)60635-7. - DOI - PubMed
    1. Exarchou S., Lindstrom U., Askling J., Eriksson J.K., Forsblad-d’Elia H., Neovius M., Turesson C., Kristensen L.E., Jacobsson L.T. The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: A nationwide register study. Arthritis Res. Ther. 2015;17:118. doi: 10.1186/s13075-015-0627-0. - DOI - PMC - PubMed