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. 2023 Feb 8;12(2):355.
doi: 10.3390/antibiotics12020355.

Outpatient Parenteral Antimicrobial Therapy for Infective Endocarditis-Model of Care

Dylan Rajaratnam  1 , Rohan Rajaratnam  1   2   3
Affiliations

Outpatient Parenteral Antimicrobial Therapy for Infective Endocarditis-Model of Care

Dylan Rajaratnam et al. Antibiotics (Basel). .

Abstract

Infective endocarditis (IE) is a serious infectious disease with significant mortality and morbidity placing a burden on healthcare systems. Outpatient antimicrobial therapy in selected patients has been shown to be safe and beneficial to both patients and the healthcare system. In this article, we review the literature on the model of care for outpatient parenteral antimicrobial therapy in infective endocarditis and propose that systems of care be developed based on local resources and all patients admitted with infective endocarditis be screened appropriately for outpatient antimicrobial therapy.

Keywords: OPAT; infective endocarditis; multidisciplinary team.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Suggested OPAT pathway. IE: infective endocarditis; IV: intravenous.
See this image and copyright information in PMC

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References

    1. Rajani R., Klein J.L. Infective endocarditis: A contemporary update. Clin. Med. 2020;20:31–35. - PMC - PubMed
    1. Cahill T.J., Baddour L.M., Habib G., Hoen B., Salaun E., Pettersson G.B., Schäfers H.J., Prendergast B.D. Challenges in Infective Endocarditis. J. Am. Coll. Cardiol. 2017;69:325–344. doi: 10.1016/j.jacc.2016.10.066. - DOI - PubMed
    1. Nishimura R.A., Otto C.M., Bonow R.O., Carabello B.A., Erwin J.P., 3rd, Gentile F., Jneid H., Krieger E.V., Mack M., McLeod C., et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J. Thorac. Cardiovasc. Surg. 2014;148:e1–e132. doi: 10.1016/j.jtcvs.2014.05.014. - DOI - PubMed
    1. Pajarón M., Fernández-Miera M.F., Allende I., Arnaiz A.M., Gutiérrez-Cuadra M., Cobo-Belaustegui M., Armiñanzas C., de Berrazueta J.R., Fariñas M.C., Sanroma P. Self-administered outpatient parenteral antimicrobial therapy (S-OPAT) for infective endocarditis: A safe and effective model. Eur. J. Intern. Med. 2015;26:131–136. doi: 10.1016/j.ejim.2015.01.001. - DOI - PubMed
    1. Larioza J., Heung L., Girard A., Brown R.B. Management of infective endocarditis in outpatients: Clinical experience with outpatient parenteral antibiotic therapy. South. Med. J. 2009;102:575–579. doi: 10.1097/SMJ.0b013e3181a4eef2. - DOI - PubMed

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