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. 2023 Feb 20;13(4):795.
doi: 10.3390/diagnostics13040795.

Timing of Early Postoperative MRI following Primary Glioblastoma Surgery-A Retrospective Study of Contrast Enhancements in 311 Patients

Alexander Malcolm Rykkje  1   2 , Vibeke Andrée Larsen  1 , Jane Skjøth-Rasmussen  3 , Michael Bachmann Nielsen  1   2 , Jonathan Frederik Carlsen  1 , Adam Espe Hansen  1   2
Affiliations

Timing of Early Postoperative MRI following Primary Glioblastoma Surgery-A Retrospective Study of Contrast Enhancements in 311 Patients

Alexander Malcolm Rykkje et al. Diagnostics (Basel). .

Abstract

An early postoperative MRI is recommended following Glioblastoma surgery. This retrospective, observational study aimed to investigate the timing of an early postoperative MRI among 311 patients. The patterns of the contrast enhancement (thin linear, thick linear, nodular, and diffuse) and time from surgery to the early postoperative MRI were recorded. The primary endpoint was the frequencies of the different contrast enhancements within and beyond the 48-h from surgery. The time dependence of the resection status and the clinical parameters were analysed as well. The frequency of the thin linear contrast enhancements significantly increased from 99/183 (50.8%) within 48-h post-surgery to 56/81 (69.1%) beyond 48-h post-surgery. Similarly, MRI scans with no contrast enhancements significantly declined from 41/183 (22.4%) within 48-h post-surgery to 7/81 (8.6%) beyond 48-h post-surgery. No significant differences were found for the other types of contrast enhancements and the results were robust in relation to the choice of categorisation of the postoperative periods. Both the resection status and the clinical parameters were not statistically different in patients with an MRI performed before and after 48 h. The findings suggest that surgically induced contrast enhancements are less frequent when an early postoperative MRI is performed earlier than 48-h, supporting the recommendation of a 48-h window for an early postoperative MRI.

Keywords: Glioblastoma; early postoperative MRI; magnetic-resonance imaging; neuroimaging; postoperative enhancement; postoperative period; time window.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Overview of the data categorisation process. Enhancement patterns are specified in the left table with corresponding resection status specified in the table to the right. Several types of contrast enhancements could be present in one patient. Abbreviations: contrast enhancement (CE).
Figure 2
Figure 2
Examples of contrast enhancement. Enhancement patterns are marked with yellow arrows.
Figure 3
Figure 3
Histogram showing the time distribution of the early postoperative MRI for all patients. The x-axis represents the time from surgery to early postoperative MRI and the y-axis represents the number of patients for each hour.
See this image and copyright information in PMC

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