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Review
. 2023 Jan 28;10(2):232.
doi: 10.3390/children10020232.

Evaluation of Beta-Defensin 1 and Mannose-Binding Lectin 2 Polymorphisms in Children with Dental Caries Compared to Caries-Free Controls: A Systematic Review and Meta-Analysis

Ghazal Hemati  1 , Mohammad Moslem Imani  1 , Parsia Choubsaz  1 , Francesco Inchingolo  2 , Roohollah Sharifi  3 , Masoud Sadeghi  4 , Santosh Kumar Tadakamadla  5   6
Affiliations
Review

Evaluation of Beta-Defensin 1 and Mannose-Binding Lectin 2 Polymorphisms in Children with Dental Caries Compared to Caries-Free Controls: A Systematic Review and Meta-Analysis

Ghazal Hemati et al. Children (Basel). .

Abstract

Background and objective: Some variants in defensin beta 1 (DEFB1) and mannose-binding lectin 2 (MBL2) genes can be associated with oral diseases. Herein, we designed a systematic review and meta-analysis to evaluate the association of DEFB1 (rs11362, rs1799946, and rs1800972) and MBL2 (rs7096206 and rs1800450) polymorphisms with the susceptibility to dental caries (DC) in children. Materials and methods: A systematic literature search was conducted in the PubMed/Medline, Web of Science, Scopus, and Cochrane Library databases until 3 December 2022, without any restrictions. The odds ratio (OR), along with a 95% confidence interval (CI) of the effect sizes, are reported. Analyses including a subgroup analysis, a sensitivity analysis, and funnel plot analyses were conducted. Results: A total of 416 records were identified among the databases, and nine articles were entered into the meta-analysis. A significant relationship was found between the T allele of DEFB1 rs11362 polymorphism and DC susceptibility, and the T allele was related to an elevated risk of DC in children (OR = 1.225; 95%CI: 1.022, 1.469; p = 0.028; I2 = 0%). No other polymorphisms were associated with DC. All articles were of moderate quality. Egger's test in homozygous and dominant models demonstrated a significant publication bias for the association of DEFB1 rs1799946 polymorphism with DC risk. Conclusions: The results demonstrated that the T allele of DEFB1 rs11362 polymorphism had an elevated risk for DC in children. However, there were only few studies that evaluated this association.

Keywords: DEFB1 protein; MBL2 protein; dental caries; meta-analysis; polymorphism.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of study selection. DEFB1: beta-defensin 1. MBL2: mannose-binding lectin 2.
Figure 2
Figure 2
Forest plot showing the association between defensin beta 1 (DEFB1) rs11362 polymorphism and dental caries risk. (A) Allelic model. (B) Homozygous model. (C) Heterozygous model. (D) Dominant model. (E) Recessive model. ((i) Deciduous dentition. (ii) Permanent dentition. (iii) Mixed dentition in the study of de Oliveira et al. [14,39,41,42]).
Figure 3
Figure 3
Forest plot analyses demonstrating the relationship between defensin beta 1 (DEFB1) rs1799946 polymorphism and dental caries risk. (A) Allelic model. (B) Homozygous model. (C) Heterozygous model. (D) Dominant model. (E) Recessive model. ((i) Deciduous dentition. (ii) Permanent dentition. (iii) Mixed dentition in the study of de Oliveira et al. [39,41]).
Figure 4
Figure 4
Forest plot for association between defensin beta 1 (DEFB1) rs1800972 polymorphism and dental caries susceptibility. (A) Homozygous model. (B) Heterozygous model [14,42].
Figure 5
Figure 5
Forest plot for association between mannose-binding lectin 2 (MBL2) rs7096206 polymorphism and dental caries risk. (A) Allelic model. (B) Homozygous model. (C) Heterozygous model. (D) Dominant model. (E) Recessive model [27,40,44].
Figure 6
Figure 6
Forest plot for association between mannose-binding lectin 2 (MBL2) rs1800450 polymorphism and dental caries susceptibility. (A) Allelic model. (B) Homozygous model. (C) Heterozygous model. (D) Dominant model. (E) Recessive model [43,45].
See this image and copyright information in PMC

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