Chemometric Discrimination of Cichorium glandulosum Boiss. et Huet and Cichorium intybus L. via Their Metabolic Profiling, Antioxidative, and Hypoglycemic Activities
- PMID: 36832980
- PMCID: PMC9957518
- DOI: 10.3390/foods12040901
Chemometric Discrimination of Cichorium glandulosum Boiss. et Huet and Cichorium intybus L. via Their Metabolic Profiling, Antioxidative, and Hypoglycemic Activities
Abstract
Cichorium glandulosum Boiss. et Huet (CG) and Cichorium intybus L. (CI) are widely used as the main raw material of functional food with hepatoprotective and hypoglycemic effects. Due to the lack of comparison on the chemical ingredients and efficacy, they were often used imprecisely and interchangeably. It is necessary to distinguish between them. With the plant metabolomics based on high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-QTOF-MS) and multivariate chemometric techniques, the chemical ingredients were characterized and 59 compounds between CG and CI were classified. As for antioxidative and hypoglycemic activities in vitro, CI extraction exhibited better antioxidant activity than CG, while CG extraction showed stronger hypoglycemic activity. Furthermore, a bivariate correlation between the chemical composition and efficacy of the extract was also analyzed, and three differentially strong correlation components between CI and CG were prepared, and the antioxidative and hypoglycemic efficacies were compared in vivo and different active phenotypes were obtained. Finally, we revealed chemical and biological differences between CG and CI, providing a basis for achieving better quality control and developing more effective functional foods.
Keywords: Cichorium glandulosum Boiss. et Huet; Cichorium intybus L.; HPLC-QTOF-MS; activity comparison; plant metabolomics.
Conflict of interest statement
The authors declare no conflict of interest.
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References
-
- China Pharmacopoeia Committee . Pharmacopoeia of the People’s Republic of China. Chemical Industry Press; Beijing, China: 2015.
-
- Perović J., Tumbas Šaponjac V., Kojić J., Krulj J., Moreno D.A., García-Viguera C., Bodroža-Solarov M., Ilić N. Chicory (Cichorium Intybus L.) as a Food Ingredient—Nutritional Composition, Bioactivity, Safety, and Health Claims: A Review. Food Chem. 2021;336:127676. doi: 10.1016/j.foodchem.2020.127676. - DOI - PubMed
-
- Nishimura M., Ohkawara T., Kanayama T., Kitagawa K., Nishimura H., Nishihira J. Effects of the Extract from Roasted Chicory (Cichorium Intybus L.) Root Containing Inulin-Type Fructans on Blood Glucose, Lipid Metabolism, and Fecal Properties. J. Tradit. Complement. Med. 2015;5:161–167. doi: 10.1016/j.jtcme.2014.11.016. - DOI - PMC - PubMed
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