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. 2023 Feb 9;20(4):3015.
doi: 10.3390/ijerph20043015.

Mental Adjustment, Functional Status, and Depression in Advanced Cancer Patients

Adán Rodríguez-González  1 , Verónica Velasco-Durántez  1 , Patricia Cruz-Castellanos  2 , Raquel Hernández  3 , Ana Fernández-Montes  4 , Paula Jiménez-Fonseca  1 , Oscar A Castillo-Trujillo  1 , Miguel García-Carrasco  5 , Berta Obispo  6 , Jacobo Rogado  6 , Mónica Antoñanzas-Basa  7 , Caterina Calderon  8
Affiliations

Mental Adjustment, Functional Status, and Depression in Advanced Cancer Patients

Adán Rodríguez-González et al. Int J Environ Res Public Health. .

Abstract

Depressive symptoms are common in individuals with advanced cancer.

Objectives: This study sought to analyze the relationship between physical and functional status and depressive symptoms, and to assess the role of mental adjustment across these variables in people with advanced cancer.

Methods: A prospective, cross-sectional design was adopted. Data were collected from 748 participants with advanced cancer at 15 tertiary hospitals in Spain. Participants completed self-report measures: Brief Symptom Inventory (BSI), Mini-Mental Adjustment to Cancer (Mini-MAC) scale, and the European Organization for Research and Treatment of Cancer (EORTC) questionnaire.

Results: Depression was present in 44.3% of the participants and was more common among women, patients <65 years old, non-partnered, and those with recurrent cancer. Results revealed a negative correlation with functional status, and functional status was negatively associated with depressive symptoms. Mental adjustment affected functional status and depression. Patients having a positive attitude displayed fewer depressive symptoms, while the presence of negative attitudes increased depressive symptoms in this population.

Conclusions: Functional status and mental adjustment are key factors in the presence of depressive symptoms among people with advanced cancer. Assessment of functional status and mental adjustment should be considered when planning treatment and rehabilitation in this population.

Keywords: advanced cancer; depression; functional status; health-related quality of life; mental adjustment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the NEOetic study.
Figure 2
Figure 2
Predictive model of depressive symptoms among patients with advanced cancer. Lines present the significant pathways. ** p < 0.001.
See this image and copyright information in PMC

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References

    1. Wang Y.-H., Li J.-Q., Shi J.-F., Que J.-Y., Liu J.-J., Lappin J.M., Leung J., Ravindran A.V., Chen W.-Q., Qiao Y.-L., et al. Depression and anxiety in relation to cancer incidence and mortality: A systematic review and meta-analysis of cohort studies. Mol. Psychiatry. 2020;25:1487–1499. doi: 10.1038/s41380-019-0595-x. - DOI - PubMed
    1. Shapiro G.K., Mah K., de Vries F., Li M., Zimmermann C., Hales S., Rodin G. A cross-sectional gender-sensitive analysis of depressive symptoms in patients with advanced cancer. Palliat. Med. 2020;34:1436–1446. doi: 10.1177/0269216320947961. - DOI - PubMed
    1. Pitman A., Suleman S., Hyde N., Hodgkiss A. Depression and anxiety in patients with cancer. BMJ. 2018;361:k1415. doi: 10.1136/bmj.k1415. - DOI - PubMed
    1. Krebber A.M.H., Buffart L.M., Kleijn G., Riepma I.C., de Bree R., Leemans C.R., Becker A., Brug J., van Straten A., Cuijpers P., et al. Prevalence of depression in cancer patients: A meta-analysis of diagnostic interviews and self-report instruments. Psychooncology. 2014;23:121–130. doi: 10.1002/pon.3409. - DOI - PMC - PubMed
    1. Obispo B., Patricia P., Castellanos C., Jiménez P., Jacobo F. Anxiety and depression in patients with advanced cancer during the COVID-19 pandemic. Support. Care Cancer. 2022;30:3363–3370. doi: 10.1007/s00520-021-06789-3. - DOI - PMC - PubMed

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