. 2023 Feb 16;20(4):3470.

doi: 10.3390/ijerph20043470.

High Burden of Neurodevelopmental Delay among Children Born to Women with Obstructed Labour in Eastern Uganda: A Cohort Study

Martin Chebet^{1

2}, Milton W Musaba³, David Mukunya^{4

5}, Brian Makoko⁴, Agnes Napyo⁴, Ritah Nantale⁴, Proscovia Auma⁶, Ketty Atim⁶, Doreck Nahurira³, Seungwon Lee⁷, Dedan Okello¹, Lawrence Ssegawa⁸, Kieran Bromley⁹, Kathy Burgoine¹⁰, Grace Ndeezi¹¹, James K Tumwine^{11

12}, Julius Wandabwa³, Sarah Kiguli¹¹

Affiliations

¹ Department of Pediatrics and Child Health, Busitema University, Mbale P.O. Box 1460, Uganda.
² Department of Global Public Health and Primary Health Care, Centre for International Health, University of Bergen, 5007 Bergen, Norway.
³ Department of Obstetrics and Gynecology, Busitema University, Mbale P.O. Box 1460, Uganda.
⁴ Department of Community and Public Health, Busitema University, Mbale P.O. Box 1460, Uganda.
⁵ Department of Research, Nikao Medical Center, Kampala P.O. Box 10005, Uganda.
⁶ Department of Obstetrics and Gynecology, Mbale Regional Referral Hospital, Mbale P.O. Box 921, Uganda.
⁷ Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁸ Department of Research, Sanyu Africa Research Institute, Mbale P.O. Box 2190, Uganda.
⁹ Research Institute for Primary Care and Health Sciences, School of Medicine, Keele University, Newcastle ST5 5BG, UK.
¹⁰ Neonatal Unit, Mbale Regional Referral Hospital, Mbale P.O. Box 921, Uganda.
¹¹ Department of Pediatrics and Child Health, Makerere University, Kampala P.O. Box 7062, Uganda.
¹² Department of Pediatrics and Child Health, Kabale University, Kabale P.O. Box 317, Uganda.

PMID: 36834165
PMCID: PMC9963417
DOI: 10.3390/ijerph20043470

High Burden of Neurodevelopmental Delay among Children Born to Women with Obstructed Labour in Eastern Uganda: A Cohort Study

Martin Chebet et al. Int J Environ Res Public Health. 2023.

. 2023 Feb 16;20(4):3470.

doi: 10.3390/ijerph20043470.

Authors

Affiliations

¹ Department of Pediatrics and Child Health, Busitema University, Mbale P.O. Box 1460, Uganda.
² Department of Global Public Health and Primary Health Care, Centre for International Health, University of Bergen, 5007 Bergen, Norway.
³ Department of Obstetrics and Gynecology, Busitema University, Mbale P.O. Box 1460, Uganda.
⁴ Department of Community and Public Health, Busitema University, Mbale P.O. Box 1460, Uganda.
⁵ Department of Research, Nikao Medical Center, Kampala P.O. Box 10005, Uganda.
⁶ Department of Obstetrics and Gynecology, Mbale Regional Referral Hospital, Mbale P.O. Box 921, Uganda.
⁷ Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁸ Department of Research, Sanyu Africa Research Institute, Mbale P.O. Box 2190, Uganda.
⁹ Research Institute for Primary Care and Health Sciences, School of Medicine, Keele University, Newcastle ST5 5BG, UK.
¹⁰ Neonatal Unit, Mbale Regional Referral Hospital, Mbale P.O. Box 921, Uganda.
¹¹ Department of Pediatrics and Child Health, Makerere University, Kampala P.O. Box 7062, Uganda.
¹² Department of Pediatrics and Child Health, Kabale University, Kabale P.O. Box 317, Uganda.

PMID: 36834165
PMCID: PMC9963417
DOI: 10.3390/ijerph20043470

Abstract

Over 250 million infants in low and middle-income countries do not fulfill their neurodevelopment potential. In this study, we assessed the incidence and risk factors for neurodevelopmental delay (NDD) among children born following obstructed labor in Eastern Uganda. Between October 2021 and April 2022, we conducted a cohort study of 155 children (aged 25 to 44 months), born at term and assessed their neurodevelopment using the Malawi Developmental Assessment Tool. We assessed the gross motor, fine motor, language and social domains of neurodevelopment. The incidence of neurodevelopmental delay by 25 to 44 months was 67.7% (105/155) (95% CI: 59.8-75.0). Children belonging to the poorest wealth quintile had 83% higher risk of NDD compared to children belonging to the richest quintile (ARR (Adjusted Risk Ratio): 1.83; 95% CI (Confidence Interval): [1.13, 2.94]). Children fed the recommended meal diversity had 25% lower risk of neurodevelopmental delay compared to children who did not (ARR: 0.75; 95% CI: [0.60, 0.94]). Children who were exclusively breastfed for the first 6 months had 27% lower risk of neurodevelopmental delay compared to children who were not (ARR: 0.73; 95% CI: [0.56, 0.96]). We recommend that infants born following obstructed labor undergo neurodevelopmental delay screening.

Keywords: Eastern-Uganda; development; growth; neurodevelopmental delay; nutrition; thrive.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

See this image and copyright information in PMC

Update of

Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study.
Mukunya D, Oguttu F, Nambozo B, Nantale R, Makoko TB, Napyo A, Tumuhamye J, Wani S, Auma P, Atim K, Okello D, Wamulugwa J, Ssegawa L, Wandabwa J, Kiguli S, Chebet M, Musaba MW, Nahurira D. Mukunya D, et al. Res Sq [Preprint]. 2023 Jul 12:rs.3.rs-3121633. doi: 10.21203/rs.3.rs-3121633/v1. Res Sq. 2023. Update in: Int J Environ Res Public Health. 2023 Feb 16;20(4):3470. doi: 10.3390/ijerph20043470. PMID: 37503197 Free PMC article. Updated. Preprint.

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High Burden of Neurodevelopmental Delay among Children Born to Women with Obstructed Labour in Eastern Uganda: A Cohort Study

Affiliations

High Burden of Neurodevelopmental Delay among Children Born to Women with Obstructed Labour in Eastern Uganda: A Cohort Study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Update of

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous