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. 2023 Feb 17;20(4):3544.
doi: 10.3390/ijerph20043544.

Mortality and Years of Life Lost Due to Brain and Other Central Nervous System Cancer in Wuhan, China, from 2010 to 2019

Jiahao Chen  1 , Yan Liu  1 , Haoyu Wen  1 , Yaqiong Yan  2 , Niannian Yang  2 , Yan Guo  2 , Juan Dai  2 , Chuanhua Yu  1
Affiliations

Mortality and Years of Life Lost Due to Brain and Other Central Nervous System Cancer in Wuhan, China, from 2010 to 2019

Jiahao Chen et al. Int J Environ Res Public Health. .

Abstract

Background: Brain cancer is one of the worst types of cancer worldwide. Understanding the epidemiology of CNS cancer is critical for properly allocating healthcare resources.

Methods: We collected data on CNS cancer deaths in Wuhan, China, during 2010-2019. We constructed the cause-eliminated life tables to calculate life expectancy (LE), mortality, and years of life lost (YLLs) by age and sex. The BAPC model was used to forecast the future trends of age-standardized mortality rate (ASMR). Decomposition analysis was adopted to explore the contribution of population growth, population aging, and age-specific mortality to the change in total CNS cancer deaths.

Results: In 2019, the ASMR of CNS cancer was 3.75, and the ASYR was 135.70 in Wuhan, China. ASMR was expected to decrease to 3.43 in 2024. The age distribution of deaths due to CNS cancer was concentrated in the middle-aged and older population, with a peak in the 65-69 age group. Caidian, Jianghan, and Qingshan had the greatest ASMRs in 2019 in Wuhan, with ASMRs of 6.32, 4.78, and 4.75, respectively. Population aging is critical to the change in total CNS cancer deaths.

Conclusion: We analyzed the current status, temporal trends, and gender and age distributions of the burden of CNS cancer in Wuhan, during 2010-2019, providing a valuable reference for better lessening the CNS cancer burden.

Keywords: brain and other central nervous system cancer; disease burden.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Temporal trends of CNS cancer burden from 2010 to 2019. (A) Temporal trends of deaths, mortality, and ASMR from 2010 to 2019. (B) Temporal trends of YLLs, YLL rate, and ASYR from 2010 to 2019.
Figure 2
Figure 2
BAPC prediction of ASMR from 2010 to 2024 by gender. (A) the prediction result for both sex. (B) the prediction result for male. (C) the prediction result for female.
Figure 3
Figure 3
Deaths and YLLs related to CNS cancer by age and sex in 2010 and 2019. (A) Number of deaths in 2019. (B) Number of YLLs in 2019. (C) Number of deaths in 2010. (D) Number of YLLs in 2010.
Figure 4
Figure 4
Spatial distribution of CNS cancer burden in Wuhan between 2010 and 2019. (A) The distribution of ASMR in 2010. (B) The distribution of ASMR in 2019. (C) The distribution of ASYR in 2010. (D) The distribution of ASYR in 2019.
Figure 5
Figure 5
Decomposition analysis of change in mortality from 2010 to 2019.
See this image and copyright information in PMC

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