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Review
. 2023 Feb 6;24(4):3215.
doi: 10.3390/ijms24043215.

Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia

Shih-Chia Yeh  1 , Faith J F Cheong  1   2 , Yvonne Tay  1   2   3
Affiliations
Review

Circular RNAs and Untranslated Regions in Acute Myeloid Leukemia

Shih-Chia Yeh et al. Int J Mol Sci. .

Abstract

Before the advent of next-generation sequencing, research on acute myeloid leukemia (AML) mostly centered on protein-coding genes. In recent years, breakthroughs in RNA sequencing technologies and whole transcriptome analysis have led to the discovery that approximately 97.5% of the human genome is transcribed into non-coding RNAs (ncRNAs). This paradigm shift has led to an explosion of research interest in different classes of non-coding RNAs, such as circular RNAs (circRNAs) as well as non-coding untranslated regions (UTRs) of protein-coding messenger RNAs. The critical roles of circRNAs and UTRs in AML pathogenesis have become increasingly apparent. In this review, we discuss the cellular mechanisms of circRNAs and summarize recent studies that reveal their biological roles in AML. Furthermore, we also review the contribution of 3'UTRs to disease progression. Finally, we discuss the potential of circRNAs and 3'UTRs as new biomarkers for disease stratification and/or the prediction of treatment response and targets for the development of RNA-directed therapeutic applications.

Keywords: 3′UTR splicing; 3′untranslated region; alternative polyadenylation; circular RNA; single nucleotide polymorphism.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the biological role of circular RNAs (circRNAs) in proliferation, apoptosis, glycolytic activity, differentiation, migration and invasion, cell cycle regulation and colony formation. Figures were created with BioRender.com.
Figure 2
Figure 2
The clinical relevance of circRNAs in AML. Figures were created with BioRender.com.
Figure 3
Figure 3
Non-coding 3’UTR variations contributing to leukemogenesis. Figures were created with BioRender.com.
See this image and copyright information in PMC

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