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Review
. 2023 Feb 11;24(4):3643.
doi: 10.3390/ijms24043643.

Targeting Breast Cancer: An Overlook on Current Strategies

Domenico Iacopetta  1 , Jessica Ceramella  1 , Noemi Baldino  2 , Maria Stefania Sinicropi  1 , Alessia Catalano  3
Affiliations
Review

Targeting Breast Cancer: An Overlook on Current Strategies

Domenico Iacopetta et al. Int J Mol Sci. .

Abstract

Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause of cancer death among women worldwide. Globally, BC is the second most frequent cancer and first most frequent gynecological one, affecting women with a relatively low case-mortality rate. Surgery, radiotherapy, and chemotherapy are the main treatments for BC, even though the latter are often not aways successful because of the common side effects and the damage caused to healthy tissues and organs. Aggressive and metastatic BCs are difficult to treat, thus new studies are needed in order to find new therapies and strategies for managing these diseases. In this review, we intend to give an overview of studies in this field, presenting the data from the literature concerning the classification of BCs and the drugs used in therapy for the treatment of BCs, along with drugs in clinical studies.

Keywords: breast cancer; chemotherapy; endocrine therapy; therapeutic targets.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecular subtypes of BCs.
See this image and copyright information in PMC

References

    1. Siegel R.L., Miller K.D., Fuchs H.E., Jemal A. Cancer statistics, 2022. CA Cancer J. Clin. 2022;72:7–33. doi: 10.3322/caac.21708. - DOI - PubMed
    1. Łukasiewicz S., Czeczelewski M., Forma A., Baj J., Sitarz R., Stanisławek A. Breast cancer–epidemiology, risk factors, classification, prognostic markers, and current treatment strategies—An updated review. Cancers. 2021;13:4287. doi: 10.3390/cancers13174287. - DOI - PMC - PubMed
    1. Breast Cancer. [(accessed on 7 December 2022)]. Available online: https://www.who.int/news-room/fact-sheets/detail/breast-cancer.
    1. Giaquinto A.N., Miller K.D., Tossas K.Y., Winn R.A., Jemal A., Siegel R.L. Cancer statistics for African American/Black people 2022. CA Cancer J. Clin. 2022;72:202–229. doi: 10.3322/caac.21718. - DOI - PubMed
    1. Miller K.D., Ortiz A.P., Pinheiro P.S., Bandi P., Minihan A., Fuchs H.E., Tyson D.M., Tortolero-Luna G., Fedewa S.A., Jemal A.M., et al. Cancer statistics for the US Hispanic/Latino population, 2021. CA Cancer J. Clin. 2021;71:466–487. doi: 10.3322/caac.21695. - DOI - PubMed