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Review
. 2023 Feb 12;24(4):3688.
doi: 10.3390/ijms24043688.

Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

Jun-Ping Shiau  1 , Ya-Ting Chuang  2 , Ching-Yu Yen  3   4 , Fang-Rong Chang  5 , Kun-Han Yang  5 , Ming-Feng Hou  1   6 , Jen-Yang Tang  7   8 , Hsueh-Wei Chang  2   6   9   10
Affiliations
Review

Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

Jun-Ping Shiau et al. Int J Mol Sci. .

Abstract

Many miRNAs are known to target the AKT serine-threonine kinase (AKT) pathway, which is critical for the regulation of several cell functions in cancer cell development. Many natural products exhibiting anticancer effects have been reported, but their connections to the AKT pathway (AKT and its effectors) and miRNAs have rarely been investigated. This review aimed to demarcate the relationship between miRNAs and the AKT pathway during the regulation of cancer cell functions by natural products. Identifying the connections between miRNAs and the AKT pathway and between miRNAs and natural products made it possible to establish an miRNA/AKT/natural product axis to facilitate a better understanding of their anticancer mechanisms. Moreover, the miRNA database (miRDB) was used to retrieve more AKT pathway-related target candidates for miRNAs. By evaluating the reported facts, the cell functions of these database-generated candidates were connected to natural products. Therefore, this review provides a comprehensive overview of the natural product/miRNA/AKT pathway in the modulation of cancer cell development.

Keywords: AKT; bioactive substance; cell function; miRNA; natural products.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Overview of AKT, AKT effectors, and miRNAs and their regulation of multiple cell functions in cancer cells.
Figure 2
Figure 2
Chemical structures of the natural products mentioned in Table 3.
Figure 3
Figure 3
Schematic diagram of the natural products affecting the regulation of miRNAs that target AKT and AKT effectors to regulate multiple cell functions in cancer cells. More detailed information is provided in each of the tables above.
See this image and copyright information in PMC

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