Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 13;24(4):3751.
doi: 10.3390/ijms24043751.

Vitamin D and Diabetic Kidney Disease

Ho-Yin Huang  1   2 , Ting-Wei Lin  3 , Zi-Xuan Hong  3 , Lee-Moay Lim  3   4   5
Affiliations
Review

Vitamin D and Diabetic Kidney Disease

Ho-Yin Huang et al. Int J Mol Sci. .

Abstract

Vitamin D is a hormone involved in many physiological processes. Its active form, 1,25(OH)2D3, modulates serum calcium-phosphate homeostasis and skeletal homeostasis. A growing body of evidence has demonstrated the renoprotective effects of vitamin D. Vitamin D modulates endothelial function, is associated with podocyte preservation, regulates the renin-angiotensin-aldosterone system, and has anti-inflammatory effects. Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease worldwide. There are numerous studies supporting vitamin D as a renoprotector, potentially delaying the onset of DKD. This review summarizes the findings of current research on vitamin D and its role in DKD.

Keywords: 1,25(OH)2D3; Vitamin D; diabetic kidney disease (DKD); diabetic nephropathy (DN); vitamin D receptor (VDR).

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Metabolic pathway of Vitamin D.
Figure 2
Figure 2
The Major Role of Vitamin D in the Pathogenesis of DKD.
See this image and copyright information in PMC

References

    1. Yang S., Li A., Wang J., Liu J., Han Y., Zhang W., Li Y.C., Zhang H. Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases. Curr. Med. Chem. 2018;25:3256–3271. doi: 10.2174/0929867325666180214122352. - DOI - PMC - PubMed
    1. Sacerdote A., Dave P., Lokshin V., Bahtiyar G. Type 2 Diabetes Mellitus, Insulin Resistance, and Vitamin D. Curr. Diab. Rep. 2019;19:101. doi: 10.1007/s11892-019-1201-y. - DOI - PubMed
    1. Gil A., Plaza-Diaz J., Mesa M.D. Vitamin D: Classic and Novel Actions. Ann. Nutr. Metab. 2018;72:87–95. doi: 10.1159/000486536. - DOI - PubMed
    1. Latic N., Erben R.G. Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure. Int. J. Mol. Sci. 2020;21:6483. doi: 10.3390/ijms21186483. - DOI - PMC - PubMed
    1. Senyigit A. The association between 25-hydroxy vitamin D deficiency and diabetic complications in patients with type 2 diabetes mellitus. Diabetes Metab. Syndr. 2019;13:1381–1386. doi: 10.1016/j.dsx.2019.01.043. - DOI - PubMed

MeSH terms