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Review
. 2023 Feb 13;24(4):3749.
doi: 10.3390/ijms24043749.

Burns: Classification, Pathophysiology, and Treatment: A Review

Wojciech Żwierełło  1 , Krzysztof Piorun  2 , Marta Skórka-Majewicz  1 , Agnieszka Maruszewska  3 , Jacek Antoniewski  1 , Izabela Gutowska  1
Affiliations
Review

Burns: Classification, Pathophysiology, and Treatment: A Review

Wojciech Żwierełło et al. Int J Mol Sci. .

Abstract

Burns and their treatment are a significant medical problem. The loss of the physical barrier function of the skin opens the door to microbial invasion and can lead to infection. The repair process of the damage caused by the burn is impaired due to the enhanced loss of fluids and minerals through the burn wound, the onset of hypermetabolism with the concomitant disruption of nutrient supply, and derangements in the endocrine system. In addition, the initiated inflammatory and free radical processes drive the progression of oxidative stress, the inhibition of which largely depends on an adequate supply of antioxidants and minerals. Clinical experience and research provide more and more data to make the treatment of patients with thermal injury increasingly effective. The publication discusses disorders occurring in patients after thermal injury and the methods used at various stages of treatment.

Keywords: burns; pathophysiology; treatment.

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Conflict of interest statement

The authors declare they have no actual or potential competing financial interests.

Figures

Figure 1
Figure 1
A full-thickness 3rd degree thermal burn.
Figure 2
Figure 2
Intermediate-thickness skin grafts on a burn wound.
Figure 3
Figure 3
Alternative nutrition in patients with burn injury.
See this image and copyright information in PMC

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