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Review
. 2023 Feb 16;24(4):4018.
doi: 10.3390/ijms24044018.

Dialogue between VE-Cadherin and Sphingosine 1 Phosphate Receptor1 (S1PR1) for Protecting Endothelial Functions

Olivia Garnier  1 , Isabelle Vilgrain  1
Affiliations
Review

Dialogue between VE-Cadherin and Sphingosine 1 Phosphate Receptor1 (S1PR1) for Protecting Endothelial Functions

Olivia Garnier et al. Int J Mol Sci. .

Abstract

The endothelial cells (EC) of established blood vessels in adults remain extraordinarily quiescent in the sense that they are not actively proliferating, but they fulfill the necessary role to control the permeability of their monolayer that lines the interior of blood vessels. The cell-cell junctions between ECs in the endothelium comprise tight junctions and adherens homotypic junctions, which are ubiquitous along the vascular tree. Adherens junctions are adhesive intercellular contacts that are crucial for the organization of the EC monolayer and its maintenance and regulation of normal microvascular function. The molecular components and underlying signaling pathways that control the association of adherens junctions have been described in the last few years. In contrast, the role that dysfunction of these adherens junctions has in contributing to human vascular disease remains an important open issue. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid mediator found at high concentrations in blood which has important roles in the control of the vascular permeability, cell recruitment, and clotting that follow inflammatory processes. This role of S1P is achieved through a signaling pathway mediated through a family of G protein-coupled receptors designated as S1PR1. This review highlights novel evidence for a direct linkage between S1PR1 signaling and the mediation of EC cohesive properties that are controlled by VE-cadherin.

Keywords: VE-cadherin; adherens junctions; endothelial cells; endothelium; lysophopholipids; sphingosine 1 phosphate receptor1 (S1PR1); sphingosine-1-phosphate (S1P).

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Conflict of interest statement

No conflict of interest, financial or otherwise, are declared by the authors.

Figures

Figure 1
Figure 1
High-resolution transmission electron micrograph showing an endothelial adherens junction in adult mouse skin. EC stands for endothelial cell. The white arrows indicate the adherens junction between two overlapping ECs. The white spots are the hair follicles in the mouse skin. Scale bar is 200 nm.
Figure 2
Figure 2
Dialogue between VE-cadherin and sphingosine-1-phosphate receptor 1 (S1PR1) for protecting endothelial functions.
See this image and copyright information in PMC

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