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Editorial
. 2023 Feb 17;24(4):4081.
doi: 10.3390/ijms24044081.

Human Serum Albumin: From Molecular Aspects to Biotechnological Applications

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Editorial

Human Serum Albumin: From Molecular Aspects to Biotechnological Applications

Alessandra di Masi. Int J Mol Sci. .

Abstract

Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multidomain macromolecule that represents the main determinant of plasma oncotic pressure and the principal modulator of fluid distribution between body compartments [...].

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Fanali G., di Masi A., Trezza V., Marino M., Fasano M., Ascenzi P. Human serum albumin: From bench to bedside. Mol. Asp. Med. 2012;33:209–290. doi: 10.1016/j.mam.2011.12.002. - DOI - PubMed
    1. di Masi A., Leboffe L., Polticelli F., Tonon F., Zennaro C., Caterino M., Stano P., Fischer S., Hagele M., Muller M., et al. Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication. J. Infect. Dis. 2018;218:1424–1435. doi: 10.1093/infdis/jiy338. - DOI - PubMed
    1. Vita G.M., De Simone G., Leboffe L., Montagnani F., Mariotti D., Di Bella S., Luzzati R., Gori A., Ascenzi P., di Masi A. Human Serum Albumin Binds Streptolysin O (SLO) Toxin Produced by Group A Streptococcus and Inhibits Its Cytotoxic and Hemolytic Effects. Front. Immunol. 2020;11:507092. doi: 10.3389/fimmu.2020.507092. - DOI - PMC - PubMed
    1. Di Bella S., di Masi A., Turla S., Ascenzi P., Gouliouris T., Petrosillo N. The Protective Role of Albumin in Clostridium difficile Infection: A Step Toward Solving the Puzzle. Infect. Control. Hosp. Epidemiol. 2015;36:1478–1479. doi: 10.1017/ice.2015.221. - DOI - PubMed
    1. Di Bella S., Ascenzi P., Siarakas S., Petrosillo N., di Masi A. Clostridium difficile Toxins A and B: Insights into Pathogenic Properties and Extraintestinal Effects. Toxins. 2016;8:134. doi: 10.3390/toxins8050134. - DOI - PMC - PubMed

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