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. 2023 Feb 8;12(4):1337.
doi: 10.3390/jcm12041337.

Blood Type A1 Mismatch Does Not Affect Heart Transplant Outcomes at One Year

Louie Cao  1 , Seongkyu Kim  2 , Ellen Klapper  3 , Jon A Kobashigawa  2 , Michelle M Kittleson  2
Affiliations

Blood Type A1 Mismatch Does Not Affect Heart Transplant Outcomes at One Year

Louie Cao et al. J Clin Med. .

Abstract

There are subtypes within blood type A, termed non-A1, that have reduced expression of A antigen on cell surfaces. This can result in the development of anti-A1 antibodies. There is limited information regarding the impact of this in heart transplant (HTx) recipients. We conducted a single-center cohort study of 142 Type A HTx recipients in which we compared outcomes of a match group (an A1/O heart into an A1 recipient or a non-A1/O heart into a non-A1 recipient) with a mismatch group (an A1 heart into a non-A1 recipient or a non-A1 heart into an A1 recipient). At one year post-transplant, there were no differences between the groups in survival, freedom from non-fatal major adverse cardiovascular events, freedom from any treated rejection, or freedom from cardiac allograft vasculopathy. There was an increased hospital length of stay in the mismatch group (13.5 vs. 17.1 days, p = 0.04). Our study showed that A1 mismatch was not associated with worse outcomes at one year post-HTx.

Keywords: ABO subtype; heart transplant; rejection.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Allocation of Subjects into Match and Mismatch Groups.
Figure 2
Figure 2
Post-Transplant Outcomes at One Year Post-HTx.
See this image and copyright information in PMC

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