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. 2023 Feb 8;12(4):1357.
doi: 10.3390/jcm12041357.

Two Years' Experience of Intensive Home Hemodialysis with the Physidia S3 System: Results from the RECAP Study

Hafedh Fessi  1 , Philippe Nicoud  2   3 , Tomas Serrato  4 , Olivia Gilbert  5 , Cécile Courivaud  6 , Salima Daoud  7 , Marion Morena  8 , Michel Thomas  9 , Bernard Canaud  10 , Jean-Paul Cristol  5   8
Affiliations

Two Years' Experience of Intensive Home Hemodialysis with the Physidia S3 System: Results from the RECAP Study

Hafedh Fessi et al. J Clin Med. .

Abstract

The RECAP study reports results and outcomes (clinical performances, patient acceptance, cardiac outcomes, and technical survival) achieved with the S3 system used as an intensive home hemodialysis (HHD) platform over a three-year French multicenter study. Ninety-four dialysis patients issued from ten dialysis centers and treated more than 6 months (mean follow-up: 24 months) with S3 were included. A two-hour treatment time was maintained in 2/3 of patients to deliver 25 L of dialysis fluid, while 1/3 required up to 3 h to achieve 30 L. The additional convection volume produced by means of the SeCoHD tool (internal filtration backfiltration) was 3 L/session, and the net ultrafiltration produced to achieve dry weight was 1.4 L/session. On a weekly basis, an average 156 L of dialysate corresponding to 94 L of urea clearance when considering 85% dialysate saturation under low flow conditions was delivered. Such urea clearance was equivalent to 9.2 [8.0-13.0] mL/min weekly urea clearance and a standardized Kt/V of 2.5 [1.1-4.5]. The predialysis concentration of selected uremic markers remained remarkably stable over time. Fluid volume status and blood pressure were adequately controlled by means of a relatively low ultrafiltration rate (7.9 mL/h/kg). Technical survival on S3 was 72% and 58% at 1 and 2 years, respectively. The S3 system was easily handled and kept by patients at home, as indicated by technical survival. Patient perception was improved, while treatment burden was reduced. Cardiac features (assessed in a subset of patients) tended to improve over time. Intensive hemodialysis relying on the S3 system offers a very appealing option for home treatment with quite satisfactory results, as shown in the RECAP study throughout a two-year follow-up time, and offers the best bridging solution to kidney transplantation.

Keywords: adequacy; dialysis efficiency; dialysis quantification; intensified hemodialysis; slow daily dialysis.

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Conflict of interest statement

M.T. is an employee of Physidia. B.C. is a part-time consulting employee for Fresenius Medical Care. The other authors state no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the study population.
Figure 2
Figure 2
Evolution of the predialysis systolic blood pressure (SBP) (mean ± SEM).
Figure 3
Figure 3
Evolution of the predialysis diastolic blood pressure (DBP) (mean ± SEM).
Figure 4
Figure 4
Evolution of plasma phosphate concentrations (median ± IQR).
Figure 5
Figure 5
Evolution of plasma albumin concentrations (mean ± SEM).
Figure 6
Figure 6
Technical survival probability of continuing HHD with S3 monitor during the follow-up period.
Figure 7
Figure 7
Evolution of the professional situation.
See this image and copyright information in PMC

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