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. 2023 Feb 10;12(4):1417.
doi: 10.3390/jcm12041417.

Incidence Trend of Follicular Lymphoma in Taiwan Compared to Japan and Korea, 2001-2019

Liang-Chun Chiu  1   2 , Chih-Wen Lin  2   3 , Hung-Ju Li  4 , Jian-Han Chen  2   5   6 , Fu-Cheng Chuang  2   7 , Sheng-Fung Lin  4 , Yu Chang  8   9 , Yu-Chieh Su  2   4
Affiliations

Incidence Trend of Follicular Lymphoma in Taiwan Compared to Japan and Korea, 2001-2019

Liang-Chun Chiu et al. J Clin Med. .

Abstract

A continuous increase in follicular lymphoma has been observed in Taiwan, Japan, and South Korea over the last few decades. This study aimed to evaluate the difference in incidence trends of follicular lymphoma in Taiwan, Japan, and South Korea between 2001 and 2019. The data for the Taiwanese populations was obtained from the Taiwan Cancer Registry Database, and those for the Japanese and Korean population were retrieved from the Japan National Cancer Registry and some additional reports, both of which included population-based cancer registry data, from Japan and Korea. Follicular lymphoma accounted for 4231 cases from 2002-2019 in Taiwan, 3744 cases from 2001-2008 and 49,731 cases from 2014-2019 in Japan; and 1365 cases from 2001-2012 and 1244 cases from 2011-2016 in South Korea. The annual percentage change for each time period was 3.49% (95% confidence interval: 2.75-4.24%) in Taiwan, 12.66% (95% confidence interval [CI]: 9.59-15.81%) and 4.95% (95% CI: 2.14-7.84%) in Japan, and 5.72% (95% CI: 2.79-8.73%) and 7.93% (95% CI: -1.63-18.42%) in South Korea. Our study confirms that the increasing trends of follicular lymphoma incidence in Taiwan and Japan have been remarkable in recent years, especially the rapid increase in Japan between 2014 and 2019; however, there was no significant in-crease from 2011 to 2015 in South Korea.

Keywords: Japan; South Korea; Taiwan; follicular lymphoma; incidence trend.

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Conflict of interest statement

The authors declare that they have no conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1
Figure 1
Trends in the ASRs of FL in Taiwan, Japan and Korea. * The APC is significantly different from 0 at the alpha level of 0.05.
Figure 2
Figure 2
Trends in the ASRs of FL for males in Taiwan and Japan. * The APC is significantly different from 0 at the alpha level of 0.05.
Figure 3
Figure 3
Trends in the ASRs of FL for females in Taiwan and Japan. * The APC is significantly different from 0 at the alpha level of 0.05.
See this image and copyright information in PMC

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