Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 13;12(4):1480.
doi: 10.3390/jcm12041480.

The Polish Society of Gynecological Oncology Guidelines for the Diagnosis and Treatment of Endometrial Carcinoma (2023)

Jacek J Sznurkowski  1 , Janusz Rys  2 , Artur Kowalik  3   4 , Agnieszka Zolciak-Siwinska  5 , Lubomir Bodnar  6 , Anita Chudecka-Glaz  7 , Pawel Blecharz  8 , Aleksandra Zielinska  9 , Andrzej Marszalek  10   11 , Mariusz Bidzinski  5 , Wlodzimierz Sawicki  9
Affiliations
Review

The Polish Society of Gynecological Oncology Guidelines for the Diagnosis and Treatment of Endometrial Carcinoma (2023)

Jacek J Sznurkowski et al. J Clin Med. .

Abstract

Background: Due to the increasing amount of published data suggesting that endometrial carcinoma is a heterogenic entity with possible different treatment sequences and post-treatment follow-up, the Polish Society of Gynecological Oncology (PSGO) has developed new guidelines.

Aim: to summarize the current evidence for diagnosis, treatment, and follow-up of endometrial carcinoma and to provide evidence-based recommendations for clinical practice.

Methods: The guidelines have been developed according to standards set by the guideline evaluation tool AGREE II (Appraisal of Guidelines for Research and Evaluation). The strength of scientific evidence has been defined in agreement with The Agency for Health Technology Assessment and Tariff System (AOTMiT) guidelines for scientific evidence classification. The grades of recommendation have been based on the strength of evidence and the level of consensus of the PSGO development group.

Conclusion: Based on current evidence, both the implementation of the molecular classification of endometrial cancer patients at the beginning of the treatment sequence and the extension of the final postoperative pathological report of additional biomarkers are needed to optimize and improve treatment results as well as to pave the route for future clinical trials on targeted therapies.

Keywords: AGREE; MMRD; NSMP; POLE; TP53abn; adjuvant; endometrial cancer; follow-up; guidelines; hereditary cancer; immunotherapy.

PubMed Disclaimer

Conflict of interest statement

JJS: advisory board for GSK, Member of the Board the Polish Society of Gynecologic Oncology, paid lectures for GSK; AK: advisory board for: AstraZeneca, Amgen, GSK, paid lectures for: AstraZeneca, Amgen, GSK, Boeringher Ingelheim, Novartis, Pfizer, Thermo Fisher Scientific; LB: advisory board for GSK, AstraZeneca; personal fees from AstraZeneca, Roche, GSK and research funding and support from AstraZeneca, Roche, Novartis, MSD, Lilly, OncoQuest, Regeneron Pharmaceutical, Gilead, Amgen, Exelixis. Inc.; ACG: advisory board for GSK, AstraZeneca; paid lectures for AstraZeneca, GSK, Member of the Board the Polish Society of Gynecologic Oncology; PB: advisory board for GSK, AstraZeneca; personal fees from AstraZeneca, GSK, Member of the Board the Polish Society of Gynecologic Oncology; MB: National consultant in gynecologic on-cology, Member of the Board the Polish Society of Gynecologic Oncology; WS: Member of the Board the Polish Society of Gynecologic Oncology.

References

    1. Brouwers M.C., Kho M.E., Browman G.P., Burgers J.S., Cluzeau F., Feder G., Fervers B., Graham I.D., Grimshaw J., Hanna S.E., et al. AGREE II: Advancing guideline development, reporting and evaluation in health care. CMAJ. 2010;182:E839–E842. doi: 10.1503/cmaj.090449. - DOI - PMC - PubMed
    1. Wytyczne Przeprowadzania Oceny Technologii Medycznych (HTA) Załącznik do Zarządzenia nr 40/2016 Prezesa AOTMiT Oceny Technologii Medycznych i Taryfikacji z dnia 13 września 2016 r. w Sprawie Wytycznych Oceny Świadczeń Opieki Zdrowotnej. [(accessed on 8 February 2023)]; Available online: https://www.aotm.gov.pl/media/2020/07/20160913_Wytyczne_AOTMiT-1.pdf.
    1. WHO Classification of Tumours . Edditorial Board. Female Genital Tumours. 5th ed. Volume 14 International Agency for Research on Cancer; Lyon, France: 2020. (WHO Classification of Tumours Series).
    1. Bell D.W., Ellenson L.H. Molecular genetics of endometrial carcinoma. Annu. Rev. Pathol. 2019;14:339–367. doi: 10.1146/annurev-pathol-020117-043609. - DOI - PubMed
    1. Deolet E., Van Dorpe J., Van de Vijver K. Mesonephric-like adenocarcinoma of the endometrium: Diagnostic advances to spot this wolf in sheep’s clothing. A Review of the literature. J. Clin. Med. 2021;10:698. doi: 10.3390/jcm10040698. - DOI - PMC - PubMed

LinkOut - more resources