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. 2023 Feb 18;12(4):1636.
doi: 10.3390/jcm12041636.

Geriatric Assessment Implementation before Chemotherapy in MEtastatic Prostate Cancer, Results from the Real-Life Study GAMERS

Cassandre Gluszak  1 , Loïc Campion  2 , Valérie Seegers  3 , Oana Cojocarasu  4 , Jean-Marie Commer  5 , Frank Priou  6 , Frédéric Rolland  7 , Catherine Terret  8 , Sophie Abadie-Lacourtoisie  1
Affiliations

Geriatric Assessment Implementation before Chemotherapy in MEtastatic Prostate Cancer, Results from the Real-Life Study GAMERS

Cassandre Gluszak et al. J Clin Med. .

Abstract

Geriatric assessment (GA) can predict and improve treatment tolerance and estimate overall survival in older patients with cancer. Several international organizations promote GA; however, data related to its implementation in daily clinical practice are still limited. We aimed to describe GA implementation in patients over 75 years old with metastatic prostate cancer treated with docetaxel as first-line treatment, and with positive G8 screening test or frailty criteria. This retrospective real-world study included 224 patients treated from 2014 to 2021 in four French centers, including 131 patients with a theoretical indication of GA. Among the latter, 51 (38.9%) patients had GA. The main barriers to GA were the lack of systematic screening (32/80, 40.0%), unavailability of geriatric physician (20/80, 25.0%), and absence of referral despite a positive screening test (12/80, 15.0%). With GA performed in only one-third of the patients with a theoretical indication in daily clinical practice, mostly due to an absence of screening test, the use of GA is currently sub-optimal.

Keywords: G8 screening; docetaxel; geriatric assessment; implementation study; older patients; prostate cancer; real-world.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Patient flow diagram.
Figure 2
Figure 2
(A) Reasons for the absence of geriatric evaluation in the total population (N = 80). (B) Reasons for the absence of geriatric evaluation in each study center.
See this image and copyright information in PMC

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