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Review
. 2023 Feb 15;9(2):261.
doi: 10.3390/jof9020261.

Polyketides as Secondary Metabolites from the Genus Aspergillus

Xuelian Bai  1 , Yue Sheng  1 , Zhenxing Tang  2 , Jingyi Pan  1 , Shigui Wang  1 , Bin Tang  1 , Ting Zhou  1 , Lu'e Shi  1 , Huawei Zhang  3
Affiliations
Review

Polyketides as Secondary Metabolites from the Genus Aspergillus

Xuelian Bai et al. J Fungi (Basel). .

Abstract

Polyketides are an important class of structurally diverse natural products derived from a precursor molecule consisting of a chain of alternating ketone and methylene groups. These compounds have attracted the worldwide attention of pharmaceutical researchers since they are endowed with a wide array of biological properties. As one of the most common filamentous fungi in nature, Aspergillus spp. is well known as an excellent producer of polyketide compounds with therapeutic potential. By extensive literature search and data analysis, this review comprehensively summarizes Aspergillus-derived polyketides for the first time, regarding their occurrences, chemical structures and bioactivities as well as biosynthetic logics.

Keywords: Aspergillus; bioactivity; fungus; polyketide; secondary metabolite; therapeutic effect.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Aspergillus-derived benzophenones (1–14).
Scheme 1
Scheme 1
Proposal biosynthetic pathways for compounds 7–14.
Figure 2
Figure 2
Aspergillus-derived diphenyl ethers (15–31).
Figure 3
Figure 3
Aspergillus-derived furans and benzofurans (32–43).
Figure 4
Figure 4
Aspergillus-derived furanones (44–76).
Figure 5
Figure 5
Aspergillus-derived tetrahydrofuranones (77–95).
Figure 6
Figure 6
Aspergillus-derived benzofuranones (96–101).
Scheme 2
Scheme 2
Proposal biosynthetic pathway for asperfuranone (33).
Scheme 3
Scheme 3
Putative biosynthetic pathway for asperochratide H (39).
Figure 7
Figure 7
Aspergillus-derived isocoumarins (102–124).
Figure 8
Figure 8
Aspergillus-derived lignans (125–136).
Figure 9
Figure 9
Aspergillus-derived naphthalenes (137–148).
Figure 10
Figure 10
Aspergillus-derived phenolic compounds (149–176).
Figure 11
Figure 11
Aspergillus-derived polyenes (177–188).
Figure 12
Figure 12
Aspergillus-derived pyrans (189–201).
Figure 13
Figure 13
Aspergillus-derived pyranones (202–219).
Scheme 4
Scheme 4
Biosynthetic pathway for nigerpyrone (212).
Figure 14
Figure 14
Aspergillus-derived benzopyranones (220–222) and naphthopyranones (223–229).
Figure 15
Figure 15
Aspergillus-derived anthraquinones (230–269).
Figure 16
Figure 16
Aspergillus-derived benzoquinones (270–274) and naphthoquinones (275–277).
Figure 17
Figure 17
Aspergillus-derived steroids (278–281).
Figure 18
Figure 18
Aspergillus-derived meroterpenoids (282–292).
Figure 19
Figure 19
Aspergillus-derived xanthones (293–316).
Figure 20
Figure 20
Aspergillus-derived miscellaneous compounds (317–343).
See this image and copyright information in PMC

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