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Review
. 2023 Jan 17;13(2):261.
doi: 10.3390/life13020261.

Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties

Adele Chimento  1 , Maria D'Amico  1   2 , Arianna De Luca  1 , Francesca Luisa Conforti  1   2 , Vincenzo Pezzi  1 , Francesca De Amicis  1   2
Affiliations
Review

Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties

Adele Chimento et al. Life (Basel). .

Abstract

Plant-derived bioactive compounds are gaining wide attention for their multiple health-promoting activities and in particular for their anti-cancer properties. Several studies have highlighted how they can prevent cancer initiation and progression, improve the effectiveness of chemotherapy, and, in some cases, limit some of the side effects of chemotherapy agents. In this paper, we provide an update of the literature on the anti-cancer effects of three extensively studied plant-derived compounds, namely resveratrol, epigallocatechin gallate, and curcumin, with a special focus on the anti-cancer molecular mechanisms inducing apoptosis in the major types of cancers globally.

Keywords: anti-cancer actions; apoptotic cell death; bioactive compounds; chemoprevention.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 3
Figure 3
Schematic representation of the apoptotic mechanisms exerted by RSV, EGCG, and CUR in breast cancer cells. See the text for details. ↑ (increase); ↓ (decrease); Özdemi,2021 [121]; Sharifi-Rad, 2021 [122]; Kohandel, 2021 [127]; Zhang, 2020 [129]; Ali, 2020 [130]; Li, 2019 [131].
Figure 1
Figure 1
Chemical structures of resveratrol (RSV) (A), epigallocatechin gallate (EGCG) (B), and curcumin (CUR) (C), and relative natural sources. The chemical structures were taken from the PubChem Substance and Compound database. (https://pubchem.ncbi.nlm.nih.gov/) accessed on 20 December 2022.
Figure 2
Figure 2
Schematic representation of the anti-cancer pathways stimulated by RSV, EGCG, and CUR in cancer cells. See the text for details.
See this image and copyright information in PMC

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