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Review
. 2023 Jan 28;13(2):361.
doi: 10.3390/life13020361.

Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays

Muhammad Ali  1   2 , Viviana Benfante  1   2   3 , Alessandro Stefano  3 , Anthony Yezzi  4 , Domenico Di Raimondo  2 , Antonino Tuttolomondo  2 , Albert Comelli  1   5
Affiliations
Review

Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays

Muhammad Ali et al. Life (Basel). .

Abstract

Polyphenols have gained widespread attention as they are effective in the prevention and management of various diseases, including cancer diseases (CD) and rheumatoid arthritis (RA). They are natural organic substances present in fruits, vegetables, and spices. Polyphenols interact with various kinds of receptors and membranes. They modulate different signal cascades and interact with the enzymes responsible for CD and RA. These interactions involve cellular machinery, from cell membranes to major nuclear components, and provide information on their beneficial effects on health. These actions provide evidence for their pharmaceutical exploitation in the treatment of CD and RA. In this review, we discuss different pathways, modulated by polyphenols, which are involved in CD and RA. A search of the most recent relevant publications was carried out with the following criteria: publication date, 2012-2022; language, English; study design, in vitro; and the investigation of polyphenols present in extra virgin olive, grapes, and spices in the context of RA and CD, including, when available, the underlying molecular mechanisms. This review is valuable for clarifying the mechanisms of polyphenols targeting the pathways of senescence and leading to the development of CD and RA treatments. Herein, we focus on research reports that emphasize antioxidant properties.

Keywords: cancer; cellular models; in vitro; metastasis; polyphenols; rheumatoid arthritis; signaling cascade; therapeutic adjuvant.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic pathogenesis of RA. The process of immune activation and disease progression involves the activation of both the innate and adaptive immune systems.
Figure 2
Figure 2
Potential sites of an inhibitory mechanism of polyphenols in MAPK signaling pathways. ERK, extracellular signal-related kinases; JNK, c-Jun amino-terminal kinases; p38, p38 mitogen-activated protein kinase.
Figure 3
Figure 3
Potential sites of an inhibitory mechanism of polyphenols in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and the mammalian target of rapamycin (mTOR) pathways.
Figure 4
Figure 4
The figure schematically elucidates the overall summary of the review.
See this image and copyright information in PMC

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