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Review
. 2023 Jan 29;13(2):372.
doi: 10.3390/life13020372.

Is Hypovitaminosis D a Risk Factor for Heart Failure?

Asmaa Carla Hagău  1 , Amalia Pușcaș  2 , Rodica Togănel  3 , Iolanda Muntean  4
Affiliations
Review

Is Hypovitaminosis D a Risk Factor for Heart Failure?

Asmaa Carla Hagău et al. Life (Basel). .

Abstract

Several studies in recent years have shown the association between vitamin D levels and heart failure. Vitamin D deficiency is related to increased cardiovascular morbidity and mortality, with a higher risk of developing heart failure. In this systematic review, we aimed to assess recent studies that analyzed vitamin D deficiency and heart failure in adult and pediatric populations. (2) Methods: We conducted a systematic search for studies published in the following databases: PubMed and Scopus from January 2012 to October 2022. (3) Results: Most observational studies that were included found a significant association between hypovitaminosis D and heart failure. However, the beneficial role of vitamin D supplementation is still controversial due to the lack of randomized controlled trials. (4) Conclusions: Vitamin D may play an important role as a cardiovascular marker in heart failure patients. More well-designed studies are needed to investigate the relationship between vitamin D and heart failure and to determine if vitamin D supplementation could improve long-term outcomes.

Keywords: Vitamin D deficiency; adults; cardiovascular; children; heart failure; risk factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA 2022 flow diagram.
See this image and copyright information in PMC

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