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Review
. 2023 Jan 23;14(2):295.
doi: 10.3390/mi14020295.

Recent Progress on Optical Biosensors Developed for Nucleic Acid Detection Related to Infectious Viral Diseases

Ece Eksin  1 , Arzum Erdem  2
Affiliations
Review

Recent Progress on Optical Biosensors Developed for Nucleic Acid Detection Related to Infectious Viral Diseases

Ece Eksin et al. Micromachines (Basel). .

Abstract

Optical biosensors have many advantages over traditional analytical methods. They enable the identification of several biological and chemical compounds directly, instantly, and without the need of labels. Their benefits include excellent specificity, sensitivity, compact size, and low cost. In this review, the main focus is placed on the nucleic acid-based optical biosensor technologies, including colorimetric, fluorescence, surface plasmon resonance (SPR), Evanescent-Wave Optical, Fiber optic and bioluminescent optical fibre. The fundamentals of each type of biosensor are briefly explained, and particular emphasis has been placed on the achievements which have been gained in the last decade on the field of diagnosis of infectious viral diseases. Concluding remarks concerning the perspectives of further developments are discussed.

Keywords: colorimetry; fluorescence; infectious viral diseases; nucleic acid biosensor; optical biosensor; surface plasmon resonance.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The optical biosensors developed for diagnostics of infectious viral diseases.
See this image and copyright information in PMC

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References

    1. Maddali H., Miles C.E., Kohn J., O’Carroll D.M. Optical Biosensors for Virus Detection: Prospects for SARS-CoV-2/COVID-19. ChemBioChem. 2021;22:1176–1189. doi: 10.1002/cbic.202000744. - DOI - PMC - PubMed
    1. Hopkins D.S., Pekker D., Goldbart P.M., Bezryadin A. Quantum interference device made by DNA templating of superconducting nanowires. Science. 2005;308:1762–1765. doi: 10.1126/science.1111307. - DOI - PubMed
    1. Wu J., Balasubramanian S., Kagan D., Manesh K.M., Campuzano S., Wang J. Motion-based DNA detection using catalytic nanomotors. Nat. Commun. 2010;1:36. doi: 10.1038/ncomms1035. - DOI - PubMed
    1. Kerman K., Kobayashi M., Tamiya E. Recent trends in electrochemical DNA biosensor technology. Meas. Sci. Technol. 2004;15:R1–R11. doi: 10.1088/0957-0233/15/2/R01. - DOI
    1. Erdem A., Ozsoz M. Nucleic Acids as Biorecognition Element in Biosensor Development. In: Palchetti I., Mascini M., editors. Nucleic Acid Biosensors for Environmental Pollution Monitoring. Royal Society of Chemistry; London, UK: 2011. pp. 17–33.

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