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Review
. 2023 Feb 10;11(2):447.
doi: 10.3390/microorganisms11020447.

Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy

Andrea García-Llorca  1 , Georgios Kararigas  1
Affiliations
Review

Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related Diabetic Retinopathy

Andrea García-Llorca et al. Microorganisms. .

Abstract

The metabolic syndrome (MetS) is a complex disease of metabolic abnormalities, including obesity, insulin resistance, hypertension and dyslipidaemia, and it is associated with an increased risk of cardiovascular disease (CVD). Diabetic retinopathy (DR) is the leading cause of vision loss among working-aged adults around the world and is the most frequent complication in type 2 diabetic (T2D) patients. The gut microbiota are a complex ecosystem made up of more than 100 trillion of microbial cells and their composition and diversity have been identified as potential risk factors for the development of several metabolic disorders, including MetS, T2D, DR and CVD. Biomarkers are used to monitor or analyse biological processes, therapeutic responses, as well as for the early detection of pathogenic disorders. Here, we discuss molecular mechanisms underlying MetS, the effects of biological sex in MetS-related DR and gut microbiota, as well as the latest advances in biomarker research in the field. We conclude that sex may play an important role in gut microbiota influencing MetS-related DR.

Keywords: biological sex; biomarkers; cardiovascular disease; diabetic retinopathy; gut microbiota; metabolic syndrome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Key players in the pathogenesis and complications of metabolic syndrome.
Figure 2
Figure 2
Overview of underlying mechanisms in diabetic retinopathy.
See this image and copyright information in PMC

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References

    1. Huang P.L. A comprehensive definition for metabolic syndrome. Dis. Model. Mech. 2009;2:231–237. doi: 10.1242/dmm.001180. - DOI - PMC - PubMed
    1. Rochlani Y., Pothineni N.V., Kovelamudi S., Mehta J.L. Metabolic syndrome: Pathophysiology, management, and modulation by natural compounds. Ther. Adv. Cardiovasc. Dis. 2017;11:215–225. doi: 10.1177/1753944717711379. - DOI - PMC - PubMed
    1. Saely C.H., Aczel S., Marte T., Langer P., Hoefle G., Drexel H. The metabolic syndrome, insulin resistance, and cardiovascular risk in diabetic and nondiabetic patients. J. Clin. Endocrinol. Metab. 2005;90:5698–5703. doi: 10.1210/jc.2005-0799. - DOI - PubMed
    1. Fahed G., Aoun L., Bou Zerdan M., Allam S., Bou Zerdan M., Bouferraa Y., Assi H.I. Metabolic syndrome: Updates on pathophysiology and management in 2021. Int. J. Mol. Sci. 2022;23:786. doi: 10.3390/ijms23020786. - DOI - PMC - PubMed
    1. Lemieux I., Després J.-P. Metabolic syndrome: Past, present and future. Nutrients. 2020;12:3501. doi: 10.3390/nu12113501. - DOI - PMC - PubMed

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