Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 16;15(4):971.
doi: 10.3390/nu15040971.

Supplementation of Vitamin D and Mental Health in Adults with Respiratory System Diseases: A Systematic Review of Randomized Controlled Trials

Dominika Głąbska  1 , Aleksandra Kołota  1 , Katarzyna Lachowicz  1 , Dominika Skolmowska  1 , Małgorzata Stachoń  1 , Dominika Guzek  2
Affiliations

Supplementation of Vitamin D and Mental Health in Adults with Respiratory System Diseases: A Systematic Review of Randomized Controlled Trials

Dominika Głąbska et al. Nutrients. .

Abstract

Vitamin D is indicated to be beneficial for the prevention and treatment of both respiratory health and mental health problems, while mental health issues are a common consequence of diseases of the respiratory system. The aim of the presented systematic review was to gather available evidence regarding the influence of the supplementation of vitamin D on mental health in adults with respiratory system diseases obtained within randomized controlled trials (RCTs). The systematic review was conducted on the basis of the PubMed and Web of Science databases in agreement with the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), while being registered within the database of the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42020155779). A total of 8514 studies published before September 2021 were screened and 5 RCTs were included, which were assessed using the revised Cochrane risk-of-bias tool for randomized trials. Screening, inclusion, reporting, and assessment were conducted by two researchers independently. The studies focused on the assessment of patients with chronic obstructive pulmonary disease, but also increased susceptibility to respiratory tract infections, pulmonary tuberculosis, and bronchial asthma. The studies were conducted for various periods of time-from 2 months to a year-while the dose of vitamin D applied was also diverse-from 4000 IU applied daily, to 100,000 IU applied weekly, or monthly. The psychological measures applied within the studies allowed the assessment, mainly, of quality of life, but also well-being, and depression. For the majority of studies, some concerns regarding risk of bias were defined, resulting from the randomization process and selection of reported results; however, for one study, the risk was even defined as high. Within the included studies, three studies confirmed a beneficial effect of vitamin D (including those with a high risk of bias), but two studies did not confirm it. Taking into account the evidence gathered, in spite of a positive influence of vitamin D on mental health in individuals with increased susceptibility to respiratory tract infections and bronchial asthma, the conducted systematic review is not a strong confirmation of the beneficial effect of the supplementation of vitamin D on mental health in adults with respiratory system diseases.

Keywords: anxiety; asthma; chronic obstructive pulmonary disease; depression; mental health; quality of life; randomized controlled trials (RCTs); respiratory tract infection; supplementation of vitamin D; systematic review; tuberculosis of the respiratory system; vitamin D.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The procedure of identifying, selecting, assessing eligibility, and including studies.
See this image and copyright information in PMC

References

    1. National Center for Biotechnology Information (US) Genes and Disease. National Center for Biotechnology Information (US); Bethesda, MD, USA: 1998.
    1. ICD-11 for Mortality and Morbidity Statistics. [(accessed on 28 January 2023)]. Available online: https://icd.who.int/browse11/l-m/en.
    1. Shukla S.D., Swaroop Vanka K., Chavelier A., Shastri M.D., Tambuwala M.M., Bakshi H.A., Pabreja K., Mahmood M.Q., O’Toole R.F. Chronic respiratory diseases: An introduction and need for novel drug delivery approaches. Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems. Academic Press; Cambridge, MA, USA: 2020. pp. 1–31. - DOI
    1. Vos T., Barber R.M., Bell B., Bertozzi-Villa A., Biryukov S. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386:743–800. doi: 10.1016/s0140-6736(15)60692-4. - DOI - PMC - PubMed
    1. Cappa V., Marcon A., Di Gennaro G., Chamitava L., Cazzoletti L., Bombieri C., Nicolis M., Perbellini L., Sembeni S., de Marco R., et al. Health-related quality of life varies in different respiratory disorders: A multi-case control population based study. BMC Pulm. Med. 2019;19:32. doi: 10.1186/s12890-019-0796-8. - DOI - PMC - PubMed

Publication types