Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 16;15(4):983.
doi: 10.3390/nu15040983.

Controversial Impact of Vitamin D Supplementation on Reducing Insulin Resistance and Prevention of Type 2 Diabetes in Patients with Prediabetes: A Systematic Review

Agata Pieńkowska  1 , Justyna Janicka  1 , Michał Duda  1 , Karena Dzwonnik  1 , Kamila Lip  1 , Aleksandra Mędza  1 , Agnieszka Szlagatys-Sidorkiewicz  1 , Michał Brzeziński  1
Affiliations

Controversial Impact of Vitamin D Supplementation on Reducing Insulin Resistance and Prevention of Type 2 Diabetes in Patients with Prediabetes: A Systematic Review

Agata Pieńkowska et al. Nutrients. .

Abstract

Background: Prediabetes has become a worldwide health problem. Multiple clinical trials have been conducted to determine the potential benefits of vitamin D supplementation in preventing the conversion to diabetes, but the results are inconsistent. The aims of this study were to evaluate the current knowledge and to suggest recommendations for researchers on designing future trials regarding that matter.

Methods: Four databases were searched for randomized control trials from the last 10 years about vitamin D and insulin resistance. The systematic electronic literature search identified 2645 studies, of which thirty-eight qualified for full-text reading and discussion. Finally, eight trials were included.

Results: Final results of seven trials reported that supplementation of vitamin D does not reduce insulin resistance nor reduces the risk of diabetes mellitus type 2 development in prediabetes. Only one trial showed improvements in fasting glucose and HOMA-IR.

Conclusions: Due to the great variation and biases in study designs, an unambiguous interpretation of the results is not possible. To eliminate those vulnerabilities in the future, we made certain suggestions for study design. Long-term and well-designed studies are still required.

Keywords: insulin resistance; prediabetes; type 2 diabetes; vitamin D.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Article selection.
See this image and copyright information in PMC

References

    1. Cohen A.J., Brauer M., Burnett R., Anderson H.R., Frostad J., Estep K., Balakrishnan K., Brunekreef B., Dandona L., Dandona R., et al. Estimates and 25-Year Trends of the Global Burden of Disease Attributable to Ambient Air Pollution: An Analysis of Data from the Global Burden of Diseases Study 2015. Lancet. 2017;389:1907–1918. doi: 10.1016/S0140-6736(17)30505-6. - DOI - PMC - PubMed
    1. Mokdad A.H., Forouzanfar M.H., Daoud F., Mokdad A.A., El Bcheraoui C., Moradi-Lakeh M., Kyu H.H., Barber R.M., Wagner J., Cercy K., et al. Global Burden of Diseases, Injuries, and Risk Factors for Young People’s Health during 1990-2013: A Systematic Analysis for the Global Burden of Disease Study 2013. Lancet. 2016;387:2383–2401. doi: 10.1016/S0140-6736(16)00648-6. - DOI - PubMed
    1. Lovic D., Piperidou A., Zografou I., Grassos H., Pittaras A., Manolis A. The Growing Epidemic of Diabetes Mellitus. Curr. Vasc. Pharmacol. 2020;18:104–109. doi: 10.2174/1570161117666190405165911. - DOI - PubMed
    1. Edwards C.M., Cusi K. Prediabetes: A Worldwide Epidemic. Endocrinol. Metab. Clin. N. Am. 2016;45:751–764. doi: 10.1016/j.ecl.2016.06.007. - DOI - PubMed
    1. World Health Organization . Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycaemia: Report of a WHO/IDF Consultation. WHO; Geneva, Switzerland: 2006.

Publication types

MeSH terms