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. 1987 Oct 5;80(3):298-302.
doi: 10.1016/0304-3940(87)90471-x.

Levels of prodynorphin mRNA in rat dentate gyrus are decreased during hippocampal kindling

B J Morris  1 , M E Moneta, G ten Bruggencate, V Höllt
Affiliations

Levels of prodynorphin mRNA in rat dentate gyrus are decreased during hippocampal kindling

B J Morris et al. Neurosci Lett. .

Abstract

The effect of hippocampal kindling on the levels of prodynorphin mRNA in rat hippocampus was examined by in situ hybridization using a synthetic oligonucleotide probe. Cryostat tissue sections were hybridised with a 32P-labelled 100 mer DNA probe complementary to the coding region of rat prodynorphin mRNA, and exposed to X-ray film. In rats exhibiting stage 4 seizures, the levels of prodynorphin mRNA in the dentate gyrus were dramatically reduced compared to control animals. This suggests that the development of kindling is accompanied by a reduction in the rate of synthesis of peptides derived from prodynorphin.

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