Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 18;15(2):695.
doi: 10.3390/pharmaceutics15020695.

Drug Delivery Systems in Regenerative Medicine: An Updated Review

Affiliations
Review

Drug Delivery Systems in Regenerative Medicine: An Updated Review

Alaa Mansour et al. Pharmaceutics. .

Abstract

Modern drug discovery methods led to evolving new agents with significant therapeutic potential. However, their properties, such as solubility and administration-related challenges, may hinder their benefits. Moreover, advances in biotechnology resulted in the development of a new generation of molecules with a short half-life that necessitates frequent administration. In this context, controlled release systems are required to enhance treatment efficacy and improve patient compliance. Innovative drug delivery systems are promising tools that protect therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. The present review provides an overview of different approaches used for drug delivery.

Keywords: drug delivery; nanoparticles; regeneration.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Examples of techniques and drug delivery systems tested in regenerative medicine: (A) 3D Bioprinting, (B) Electrospinning, (C) Extracellular vesicles, (D) Liposome, (E) Polymeric micelles.

References

    1. Mao A.S., Mooney D.J. Regenerative medicine: Current therapies and future directions. Proc. Natl. Acad. Sci. USA. 2015;112:14452-9. doi: 10.1073/pnas.1508520112. - DOI - PMC - PubMed
    1. Vacanti J.P., Otte J.-B., Wertheim J.A. Regenerative Medicine Applications in Organ Transplantation. Elsevier; Amsterdam, The Netherlands: 2014. Introduction: Regenerative medicine and solid organ transplantation from a historical perspective; pp. 1–15.
    1. Muzzio N., Moya S., Romero G. Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative Medicine. Pharmaceutics. 2021;13:792. doi: 10.3390/pharmaceutics13060792. - DOI - PMC - PubMed
    1. Filipczak N., Yalamarty S.S.K., Li X., Khan M.M., Parveen F., Torchilin V. Lipid-Based Drug Delivery Systems in Regenerative Medicine. Materials. 2021;14:5371. doi: 10.3390/ma14185371. - DOI - PMC - PubMed
    1. del Amo E.M., Rimpelä A.-K., Heikkinen E., Kari O.K., Ramsay E., Lajunen T., Schmitt M., Pelkonen L., Bhattacharya M., Richardson D., et al. Pharmacokinetic aspects of retinal drug delivery. Prog. Retin. Eye Res. 2017;57:134–185. doi: 10.1016/j.preteyeres.2016.12.001. - DOI - PubMed

LinkOut - more resources