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Review
. 2023 Feb 22;61(2):e0054822.
doi: 10.1128/jcm.00548-22. Epub 2023 Feb 22.

The Brief Case: the Cryptic Cryptococcus

Anisha Misra  1 , Zachary A Yetmar  2 , Amber A Milone  1 , Lydia A Ruefthaler  1 , Nancy L Wengenack  1 , Paschalis Vergidis  2 , Elitza S Theel  1
Affiliations
Review

The Brief Case: the Cryptic Cryptococcus

Anisha Misra et al. J Clin Microbiol. .
No abstract available

Keywords: Cryptococcus; antigen; capsule deficient; fungemia; solid-organ transplantation; unencapsulated.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIG 1
FIG 1
India Ink stain of capsule-deficient Cryptococcus. In the presence of a capsule India ink displaces around the capsule, creating a clearing around the yeast cells. Lack of clearing around the cells is indicative of unencapsulated Cryptococcus.
FIG 2
FIG 2
Capsule modulation by Cryptococcus over time in vitro. (a) Nonmucoid cultures on Sabouraud’s dextrose agar (SDA) from original specimen 4 days postculturing; (b) India ink staining of culture indicating no visible capsule production; (c) mucoid Cryptococcus colonies following 10 days of subculture on SDA; (d) India ink staining of mucoid colonies, with clearing indicating the presence of a capsule.
See this image and copyright information in PMC

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