Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Apr;32(4):e4602.
doi: 10.1002/pro.4602.

Comment on "Intrinsic protein disorder uncouples affinity from binding specificity"

Affiliations
Comment

Comment on "Intrinsic protein disorder uncouples affinity from binding specificity"

Kaare Teilum et al. Protein Sci. 2023 Apr.
No abstract available

PubMed Disclaimer

Figures

FIGURE 1
FIGURE 1
Density estimates of ΔG° of binding for IDP:ordered complexes (ID‐OR, red) and for complexes between two globular ordered proteins (OR‐OR, blue). The distributions in light colors are from the data compiled by Lazar et al. (2022), whereas the distributions in darker colors are from the data compiled by Teilum et al. (2015). The dashed vertical lines show the average of each distribution.

Comment in

Comment on

Similar articles

References

    1. Eaton BE, Gold L, Zichi DA. Let's get specific: the relationship between specificity and affinity. Chem Biol. 1995;2:633–8. - PubMed
    1. Lazar T, Tantos A, Tompa P, Schad E. Intrinsic protein disorder uncouples affinity from binding specificity. Protein Sci. 2022;31:e4455. - PMC - PubMed
    1. Pauwels K, Tompa P. Editorial: function and flexibility: friend or foe? Front Mol Biosci. 2016;3:31. - PMC - PubMed
    1. Teilum K, Olsen JG, Kragelund BB. Globular and disordered—the non‐identical twins in protein‐protein interactions. Front Mol Biosci. 2015;2:40. - PMC - PubMed
    1. Teilum K, Olsen JG, Kragelund BB. On the specificity of protein–protein interactions in the context of disorder. Biochem J. 2021;478:2035–50. - PMC - PubMed

LinkOut - more resources