Emerging role of inositol monophosphatase in cancer
- PMID: 36841024
- DOI: 10.1016/j.biopha.2023.114442
Emerging role of inositol monophosphatase in cancer
Abstract
Inositol monophosphatase (IMPase) is an enzyme with two homologs-IMPA1 and IMPA2-that is responsible for dephosphorylating myo-inositol monophosphate to generate myo-inositol. IMPase has been extensively studied in neuropsychiatric diseases and is regarded as a susceptibility gene. Recently, emerging evidence has implied that IMPase is linked to cancer development and progression and correlates with patient survival outcomes. Interestingly, whether it acts as a tumor-promoter or tumor-suppressor is inconsistent among different research studies. In this review, we summarize the latest findings on IMPase in cancer, focusing on exploring the underlying mechanisms for its pro- and anticancer roles. In addition, we discuss the potential methods of IMPase regulation in cancer cells and the possible approaches for IMPase intervention in clinical practice.
Keywords: Cancer; IMPA1; IMPA2; IMPase; Myo-inositol.
Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Conflict of interest statement
Conflict of interest statement The authors declare that there are no conflicts of interest. Fig. 1 B was created by ESPript 3.0 (https://espript.ibcp.fr/ESPript/cgi-bin/ESPript.cgi). Figs. 2, 3, and 5 were created by Figdraw (www.figdraw.com). Fig. 4 was created by GEPIA (http://gepia.cancer-pku.cn/).
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