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Review
. 2023 May:161:114442.
doi: 10.1016/j.biopha.2023.114442. Epub 2023 Feb 24.

Emerging role of inositol monophosphatase in cancer

Qian Chen  1 , Liangfang Shen  1 , Shan Li  2
Affiliations
Free article
Review

Emerging role of inositol monophosphatase in cancer

Qian Chen et al. Biomed Pharmacother. 2023 May.
Free article

Abstract

Inositol monophosphatase (IMPase) is an enzyme with two homologs-IMPA1 and IMPA2-that is responsible for dephosphorylating myo-inositol monophosphate to generate myo-inositol. IMPase has been extensively studied in neuropsychiatric diseases and is regarded as a susceptibility gene. Recently, emerging evidence has implied that IMPase is linked to cancer development and progression and correlates with patient survival outcomes. Interestingly, whether it acts as a tumor-promoter or tumor-suppressor is inconsistent among different research studies. In this review, we summarize the latest findings on IMPase in cancer, focusing on exploring the underlying mechanisms for its pro- and anticancer roles. In addition, we discuss the potential methods of IMPase regulation in cancer cells and the possible approaches for IMPase intervention in clinical practice.

Keywords: Cancer; IMPA1; IMPA2; IMPase; Myo-inositol.

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Conflict of interest statement

Conflict of interest statement The authors declare that there are no conflicts of interest. Fig. 1 B was created by ESPript 3.0 (https://espript.ibcp.fr/ESPript/cgi-bin/ESPript.cgi). Figs. 2, 3, and 5 were created by Figdraw (www.figdraw.com). Fig. 4 was created by GEPIA (http://gepia.cancer-pku.cn/).

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