Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2023 May;128(9):1690-1700.
doi: 10.1038/s41416-023-02207-z. Epub 2023 Feb 25.

Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic

Michelle Harvie  1   2   3   4 , David P French  5   6   7 , Mary Pegington  8   5   9 , Cheryl Lombardelli  8 , Suzy Krizak  8 , Katharine Sellers  8 , Emma Barrett  10 , D Gareth Evans  8   5   6   11 , Ramsey Cutress  12 , Andrea Wilding Rgn  8   13 , Lee Graves  14 , Anthony Howell  8   5   6   9   15
Affiliations
Randomized Controlled Trial

Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic

Michelle Harvie et al. Br J Cancer. 2023 May.

Abstract

Background: Overweight and obesity are common amongst women attending breast cancer Family History, Risk and Prevention Clinics (FHRPCs). Overweight increases risk of breast cancer (BC) and conditions including1 cardiovascular disease (CVD) and type-2 diabetes (T2D). Clinics provide written health behaviour advice with is likely to have minimal effects. We assessed efficacy of two remotely delivered weight loss programmes vs. written advice.

Method: 210 women with overweight or obesity attending three UK FHRPCs were randomised to either a BC prevention programme (BCPP) framed to reduce risk of BC (n = 86), a multiple disease prevention programme (MDPP) framed to reduce risk of BC, CVD and T2D (n = 87), or written advice (n = 37). Change in weight and health behaviours were assessed at 12-months.

Results: Weight loss at 12 months was -6.3% (-8.2, -4.5) in BCPP, -6.0% (-7.9, -4.2) in MDPP and -3.3% (-6.2, -0.5) in the written group (p = 0.451 across groups). The percentage losing ≥10% weight in these groups were respectively 34%, 23% and 14% (p = 0.038 across groups).

Discussion: BCPP and MDPP programmes resulted in more women achieving ≥10% weight loss, but no evidence of additional benefits of MDPP. A multicentre RCT to test the BCPP across UK FHRPCs is warranted. Clinical Trial Registration ISRCTN16431108.

PubMed Disclaimer

Conflict of interest statement

RC: medical body composition analysers have been provided by SECA to UHS as part of an investigator-led Collaborative Research Agreement between SECA GmbH & Co. KG. (Hamburg, Germany), UHS and the University of Southampton. Also institutional research funding by Astra Zeneca (unrelated to this study). The other authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Components of the BCPP, MDPP and written advice.
Fig. 2
Fig. 2
Consolidated Standards of Reporting Trials (CONSORT) flow diagram of patients recruited to the trial.
Fig. 3
Fig. 3
Percentage weight loss in the 3 groups over 12 months ANCOVA estimated marginal means for completers and intention to treat using imputed data.
See this image and copyright information in PMC

References

    1. Gramling R, Lash TL, Rothman KJ, Cabral HJ, Silliman R, Roberts M, et al. Family history of later-onset breast cancer, breast healthy behavior and invasive breast cancer among postmenopausal women: a cohort study. Breast Cancer Res. 2010;12:R82. doi: 10.1186/bcr2727. - DOI - PMC - PubMed
    1. Hopper JL, Dite GS, MacInnis RJ, Liao Y, Zeinomar N, Knight JA, et al. Age-specific breast cancer risk by body mass index and familial risk: prospective family study cohort (ProF-SC) Breast Cancer Res. 2018;20:132. doi: 10.1186/s13058-018-1056-1. - DOI - PMC - PubMed
    1. Kehm RD, Genkinger JM, MacInnis RJ, John EM, Phillips KA, Dite GS, et al. Recreational physical activity is associated with reduced breast cancer risk in adult women at high risk for breast cancer: a cohort study of women selected for familial and genetic risk. Cancer Res. 2020;80:116–25. doi: 10.1158/0008-5472.CAN-19-1847. - DOI - PMC - PubMed
    1. Zeinomar N, Knight JA, Genkinger JM, Phillips KA, Daly MB, Milne RL, et al. Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC) Breast Cancer Res. 2019;21:128. doi: 10.1186/s13058-019-1213-1. - DOI - PMC - PubMed
    1. Petimar J, Park YM, Smith-Warner SA, Fung TT, Sandler DP. Dietary index scores and invasive breast cancer risk among women with a family history of breast cancer. Am J Clin Nutr. 2019;109:1393–401. doi: 10.1093/ajcn/nqy392. - DOI - PMC - PubMed

Publication types