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Review
. 2023 May-Jun:59:173-180.
doi: 10.1016/j.hrtlng.2023.02.003. Epub 2023 Feb 8.

Cardiovascular complications of COVID-19 vaccines: A review of case-report and case-series studies

Mohammad Hossein Paknahad  1 , Fatereh Baharlouei Yancheshmeh  1 , Azam Soleimani  2
Affiliations
Review

Cardiovascular complications of COVID-19 vaccines: A review of case-report and case-series studies

Mohammad Hossein Paknahad et al. Heart Lung. 2023 May-Jun.

Abstract

Background: There are multiple reviews on cardiovascular aspects of COVID-19 disease on cardiovascular system in different population but there is lack of evidence about cardiovascular adverse effects of COVID vaccines.

Objectives: The purpose of this study was to compare the cardiac complications of COVID19 vaccines, based on vaccine type (mRNA, vector-based, and inactivated vaccines).

Methods: A systematic search was performed covering PubMed for English case-reports and case-series studies, and finally 100 studies were included.

Results: Myocarditis (with overall rate around 1.62%) was shown to be the most common post-COVID19 immunization cardiac event. More than 90% of post-COVID19 vaccination myocarditis occurred after receiving mRNA vaccines (Moderna & Pfizer-BioNTech), but the report of this event was less in the case of vector-based vaccinations and/or inactivated vaccines. Myocarditis was reported more commonly in men and following the second dose of the immunization. Takotsubo cardiomyopathy (TTC) was reported after mRNA (more commonly) and vector-based vaccinations, with no case report after inactivated vaccines. When mRNA and vector-based vaccinations were used instead of inactivated vaccines, a greater frequency of vaccine-induced thrombotic thrombocytopenia (VITT) and pulmonary emboli (PE) was reported. Myocardial infarction/cardiac arrest was recorded in those beyond the age of 75 years.

Conclusion: The personal and public health benefits of COVID-19 vaccination much outweigh the minor cardiac risks. Reporting bias, regarding more available mRNA vaccines in developed countries, may conflict these results.

Keywords: Adenoviral vector vaccine; COVID-19; Cardiovascular complications; Inactivated vaccine; Review; mRNA vaccine.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:

Figures

Fig 1
Fig. 1
Flowchart of study selection.
See this image and copyright information in PMC

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References

    1. Soleimani A., Soleimani Z. Presentation and outcome of congenital heart disease during COVID-19 pandemic: a review. Curr Probl Cardiol. 2022;47(1) - PMC - PubMed
    1. Hantoushzadeh S., Nabavian S.M., Soleimani Z., Soleimani A. COVID-19 disease during pregnancy and peripartum period: a cardiovascular review. Curr Probl Cardiol. 2022;47(1) - PMC - PubMed
    1. Chandra A., Gurjar V., Qamar I., Singh N. Exploring potential inhibitor of SARS-CoV2 replicase from FDA approved drugs using insilico drug discovery methods. J Biomol Struct Dyn. 2021 - PubMed
    1. Xia S., Duan K., Zhang Y., Zhao D., Zhang H., Xie Z., et al. Effect of an inactivated vaccine against SARS-CoV-2 on safety and immunogenicity outcomes: interim analysis of 2 randomized clinical trials. JAMA. 2020;324(10):951–960. - PMC - PubMed
    1. Ho J.S., Sia C.H., Ngiam J.N., Loh P.H., Chew N.W., Kong W.K., et al. A review of COVID-19 vaccination and the reported cardiac manifestations. Singapore Med J. 2021 - PMC - PubMed