Alterations in pain during adolescence and puberty

Hadas Nahman-Averbuch¹, Rui Li², Katelynn E Boerner³, Christopher Lewis⁴, Sarah Garwood⁵, Tonya M Palermo⁶, Abbie Jordan⁷

Affiliations

¹ Washington University Pain Center and Division of Clinical and Translational Research, Department of Anesthesiology, Washington University in St Louis School of Medicine, St. Louis, MO, USA. Electronic address: hadas@wustl.edu.
² Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA.
³ Department of Pediatrics, University of British Columbia, and BC Children's Hospital Research Institute, Vancouver, BC, Canada.
⁴ Division of Endocrinology and Diabetes, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; Transgender Center at St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
⁵ Transgender Center at St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
⁶ Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA; Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA.
⁷ Department of Psychology and Centre for Pain Research, University of Bath, Bath, United Kingdom.

PMID: 36842946
DOI: 10.1016/j.tins.2023.01.006

Review

Alterations in pain during adolescence and puberty

Hadas Nahman-Averbuch et al. Trends Neurosci. 2023 Apr.

. 2023 Apr;46(4):307-317.

doi: 10.1016/j.tins.2023.01.006. Epub 2023 Feb 24.

Authors

Hadas Nahman-Averbuch¹, Rui Li², Katelynn E Boerner³, Christopher Lewis⁴, Sarah Garwood⁵, Tonya M Palermo⁶, Abbie Jordan⁷

Affiliations

¹ Washington University Pain Center and Division of Clinical and Translational Research, Department of Anesthesiology, Washington University in St Louis School of Medicine, St. Louis, MO, USA. Electronic address: hadas@wustl.edu.
² Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA.
³ Department of Pediatrics, University of British Columbia, and BC Children's Hospital Research Institute, Vancouver, BC, Canada.
⁴ Division of Endocrinology and Diabetes, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; Transgender Center at St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
⁵ Transgender Center at St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
⁶ Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA; Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA.
⁷ Department of Psychology and Centre for Pain Research, University of Bath, Bath, United Kingdom.

PMID: 36842946
DOI: 10.1016/j.tins.2023.01.006

Abstract

During adolescence and puberty, alterations in pain, both experimental and clinical, are observed. In addition, adolescents undergo extensive biopsychosocial changes as they transition from childhood to adulthood. However, a better understanding of how the biopsychosocial changes during adolescence impact pain is needed to improve pain management and develop targeted pain interventions for adolescents. This review synthesizes the literature on alterations in pain during adolescence in humans, describes the potential biopsychosocial factors impacting pain during adolescence, and suggests future research directions to advance the understanding of the impact of adolescent development on pain.

Keywords: biopsychosocial; brain; development; hormones; nociception; sex.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests in relation to this work.

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Alterations in pain during adolescence and puberty

Affiliations

Alterations in pain during adolescence and puberty

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical