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. 2023 May;46(5):333-335.
doi: 10.1016/j.tins.2023.02.003. Epub 2023 Feb 24.

How iron can drive neurodegeneration

Boyd Kenkhuis  1 , Ashley I Bush  2 , Scott Ayton  3
Affiliations

How iron can drive neurodegeneration

Boyd Kenkhuis et al. Trends Neurosci. 2023 May.

Abstract

Iron overload in neurodegenerative diseases is well established but of uncertain significance. In a recent article, Ryan et al. reveal that microglia are especially vulnerable to iron overload-induced ferroptosis. Their evidence for microglial ferroptosis in clinical specimens indicates that ferroptosis inhibitors may hold therapeutic promise for these diseases.

Keywords: Alzheimer's disease; Parkinson's disease; astrocytes, iPSC; ferroptosis; microglia.

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Conflict of interest statement

Declaration of interests A.I.B. holds equity in Alterity Ltd, Cogstate Ltd, Mesoblast Ltd and is a consultant and holds a profit share in Collaborative Medicinal Development Pty Ltd. S.A. is a consultant to Eisai Australia. B.K. declares no competing interests in relation to this work.

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