Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan-Feb;17(1):15579883231153018.
doi: 10.1177/15579883231153018.

Differences in Metabolomic Profiles by Birthplace in Mexican-Origin Hispanic Men Who Participated in a Weight Loss Lifestyle Intervention

Melissa Lopez-Pentecost  1 , David O Garcia  2   3 , Xiaoxiao Sun  4 , Cynthia A Thomson  2   3 , H-H Sherry Chow  3 , Jessica A Martinez  3   5
Affiliations

Differences in Metabolomic Profiles by Birthplace in Mexican-Origin Hispanic Men Who Participated in a Weight Loss Lifestyle Intervention

Melissa Lopez-Pentecost et al. Am J Mens Health. 2023 Jan-Feb.

Abstract

Birthplace, as a proxy for environmental exposures (e.g., diet), may influence metabolomic profiles and influence risk of cancer. This secondary analysis investigated metabolomic profile differences between foreign and U.S.-born Mexican-origin (MO) Hispanic men to shed light on potential mechanisms through which foreign- and U.S.-born individuals experience differences in cancer risk and risk factors. Plasma samples from MO Hispanic men (N = 42) who participated in a previous lifestyle intervention were collected pre-and post-intervention. Metabolomic profiles were characterized from samples using ultra performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-QTOF). Models were visualized using supervised orthogonal projections to latent structures-discriminant analysis (OPLS-DA). Progenesis QI was used for peak integration and metabolite identification. Plasma metabolomic profiles differed between foreign- and U.S.-born pre-intervention (R2 = .65) and post-intervention (R2 = .62). Metabolomic profiles differed pre- versus post-intervention (R2 = .35 and R2 = .65) for the foreign- and U.S.-born group, respectively. Both endogenous metabolites and dietary components characterized differences between foreign- and U.S.-born participants pre- and post-intervention. Plasma metabolomic profiles from MO Hispanic men differed by birthplace. These results advance our understanding of relevant exposures that may affect cancer risk among MO Hispanic men born abroad or in the United States.

Keywords: Mexican-origin Hispanic; birthplace; cancer prevention < oncology/cancer; metabolomics; weight loss.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving research study participants were approved by the The University of Arizona Institutional Review Board (IRB # 604536275). Written informed consent was obtained from all subjects involved in the study.

Figures

Figure 1.
Figure 1.
Stratification of Sample for Metabolomics Profile Comparison Among Participants From the ANIMO Pilot Study (N = 42)
Figure 2.
Figure 2.
OPLS-DA and S-Plots for Foreign-Born versus U.S.-Born Pre-Intervention and Post-Intervention. Multivariate Statistical Analysis From Ultra Performance Liquid Chromatography-Quadrupole Time of Flight Mass Spectrometry Metabolic Profiling. (A) OPLS-DA Score of Foreign-Born (Green) vs. U.S.-Born (Blue) at Pre-Intervention; (B) S-Plot With Metabolites That Were Examined (Circled in Red); (C) OPLS-DA Score of Foreign-Born (Green) vs. U.S.-Born (Blue) at Post-Intervention; (D) S-Plot With Metabolites That Were Examined (Circled in Red) in C
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Afable-Munsuz A., Mayeda E. R., Perez-Stable E. J., Haan M. N. (2013). Immigrant generation and diabetes risk among Mexican Americans: The Sacramento area Latino study on aging. American Journal of Public Health, 103(5), e45–e52. 10.2105/AJPH.2012.300969 - DOI - PMC - PubMed
    1. Akresh I. R. (2008). Overweight and obesity among foreign-born and U.S.-born Hispanics. Biodemography and Social Biology, 54(2), 183–199. 10.1080/19485565.2008.9989141 - DOI - PubMed
    1. Anderson C., Zhao H., Daniel C. R., Hromi-Fiedler A., Dong Q., Elhor Gbito K. Y., Wu X., Chow W. H. (2016). Acculturation and diabetes risk in the Mexican American Mano a Mano Cohort. American Journal of Public Health, 106(3), 547–549. 10.2105/AJPH.2015.303008 - DOI - PMC - PubMed
    1. Bagheri M., Djazayery A., Farzadfar F., Qi L., Yekaninejad M. S., Aslibekyan S., Chamari M., Hassani H., Koletzo R., Uhl O. (2019). Plasma metabolomic profiling of amino acids and polar lipids in Iranian obese adults. Lipids in Health Disease, 18(1), Article 94. 10.1186/s12944-019-1037-0 - DOI - PMC - PubMed
    1. Centers for Disease Control and Prevention. Cancers associated with overweight and obesity make up 40 percent of cancers diagnosed in the United States. (2017).

Publication types

Supplementary concepts