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Case Reports
. 2023 Jan 23;15(1):e34092.
doi: 10.7759/cureus.34092. eCollection 2023 Jan.

Degenerative Disorder of the Temporomandibular Joint Treated With Autologous Bone Marrow-Derived Stem Cells Using the Regentime Technique: A Case Report

Rita T Boulos  1 , Cynthia F Najjoum  2 , Elsa A El Asmar  3 , Nassim H Abi Chahine  4
Affiliations
Case Reports

Degenerative Disorder of the Temporomandibular Joint Treated With Autologous Bone Marrow-Derived Stem Cells Using the Regentime Technique: A Case Report

Rita T Boulos et al. Cureus. .

Abstract

Temporomandibular joint (TMJ) disease is a type of degenerative musculoskeletal disorder that leads to morphological and functional abnormalities. It has a poorly understood progression with numerous independent and interrelated factors, which makes it difficult for the available treatment options to meet long-term demands. We present the case of a 37-year-old woman who suffered from excruciating pain in the right temporomandibular joint, associated with limited mandibular movement. She was found to have imaging features of TMJ disorder. She underwent the Regentime procedure which uses autologous bone marrow-derived stem cells that are partially differentiated and redirected to the targeted tissue. Clinical follow-up showed total clinical recovery.

Keywords: autologous mononuclear stem cells; bone marrow-derived stem cells; regentime therapy; stem cell therapy; temporomandibular joint degeneration; tmj disorders.

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Conflict of interest statement

Intellectual Property Office Priority Document Access Service (PDAS) Reference: Regentime Brain Patent application number: GB1712971.9 Full name of the first applicant: Abi Chahin, Dr. Nassim Date 13 August 2017

Figures

Figure 1
Figure 1. MRI of the patient's right temporomandibular joint before stem cell therapy
MRI: Magnetic resonance imaging
Figure 2
Figure 2. MRI of the patient's right temporomandibular joint one year after stem cell therapy
MRI: Magnetic resonance imaging
See this image and copyright information in PMC

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