Toxicology as a diagnostic tool to identify the misuse of drugs in the perinatal period
- PMID: 36843886
- PMCID: PMC9944414
- DOI: 10.3389/fped.2022.1071564
Toxicology as a diagnostic tool to identify the misuse of drugs in the perinatal period
Abstract
The use, misuse, and abuse of substances are a continued public health concern in this country and around the world. Perinatal exposure to substances of abuse is associated with several long-term negative consequences for the neonate. Limited resources exist to assist perinatal health professionals on this very complex subject. The purpose of this document is to provide additional information about selecting monitoring protocols, the specifics of appropriate testing methodologies, and the interpretation of toxicological findings. Understanding these concepts better allows perinatal healthcare professionals to be a voice for the voiceless in order to protect and enrich lives during this unprecedented opioid epidemic.
Keywords: forensic testing; maternal substance use; meconium testing; newborn toxicology; prenatal drug exposure; substance abuse; umbilical cord testing.
© 2023 Jones.
Conflict of interest statement
JJ is employed by United States Drug Testing Laboratories, a national commercial reference laboratory, that is in the business of selling some of the services mentioned in this manuscript. This relationship did not influence the design or composition of this manuscript.
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References
-
- Center on Addiction and Substance Abuse (CASA). No safe haven: Children of substance abusing parents. New York: Columbia University; (1999).
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