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. 2023 Feb 16:2023:6976389.
doi: 10.1155/2023/6976389. eCollection 2023.

The Cut-Off Value of Serum Anti-Müllerian Hormone Levels for the Diagnosis of Turner Syndrome with Spontaneous Puberty

Jin Wang  1 , Tian Lan  1 , Xiang Dai  1 , Luhong Yang  1 , Xijiang Hu  1 , Hui Yao  1
Affiliations

The Cut-Off Value of Serum Anti-Müllerian Hormone Levels for the Diagnosis of Turner Syndrome with Spontaneous Puberty

Jin Wang et al. Int J Endocrinol. .

Abstract

Objective: Preservation of fertility in Turner syndrome (TS) patients may be feasible through cryopreservation of ovarian tissue before follicles begin to disappear. Anti-Müllerian hormone (AMH) is said to be a predictive factor of spontaneous pubertal development in TS. We aimed to determine the cut-off values of AMH for the diagnosis of TS girls with spontaneous puberty. Design and methods: A total of 95 TS patients between 4 and 17 years were evaluated at the Department of Pediatric Genetic Metabolism and Endocrinology from July 2017 to March 2022. Serum AMH, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were analyzed according to age, karyotype, pubertal development, and ultrasound ovarian visualization. Receiver-operating characteristic (ROC) curve analyzes were used to test the utility of AMH for the diagnosis of TS girls with spontaneous puberty.

Results: One-fourth of TS girls aged 8-17 years had spontaneous breast development, with the ratios as follows: 45, X (6/28, 21.4%), mosaicism (7/12, 58.3%), and mosaicism with structural X chromosome abnormalities (SCA) (2/13, 15.4%), SCA (1/13, 7.7%), and Y chromosome (1/3, 33.3%). The AMH cut-off value for the prediction of spontaneous puberty in TS patients was 0.07 ng/ml, with sensitivity and specificity both at 88%. FSH, LH levels, and Karyotypes could not be considered as markers of spontaneous puberty in TS (P > 0.05). A strong relationship was observed between serum AMH levels and spontaneous puberty or ultrasound bilateral ovarian visualization.

Conclusions: The AMH cut-off value for the prediction of spontaneous puberty in TS girls aged 8-17 years was 0.07 ng/ml, with sensitivity and specificity both at 88%. However, spontaneous puberty in these patients is not predictable based on karyotype or FSH or LH levels.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Serum AMH levels in TS adolescent girls with spontaneous puberty. The reference range is based on healthy Chinese girls. Lines represent the median, the 2.5th percentile, and the 97.5th percentile. Serum concentrations of AMH (ng/ml) of 95 TS patients are plotted versus age. Triangles: 45, X; diamond: mosaicism; squares: mosaicism with SCA; circle: SCA; cruciform: with Y chromosome; black: TS patients with nonspontaneous puberty; blue: TS patients with spontaneous puberty. pmol/L = ng/mL ∗ 7.14.
Figure 2
Figure 2
ROC curve showing cutoff values of AMH for predicting spontaneous puberty.
See this image and copyright information in PMC

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