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Review
. 2023 Feb 14;29(6):926-948.
doi: 10.3748/wjg.v29.i6.926.

Resistance to targeted therapy in metastatic colorectal cancer: Current status and new developments

Yuan-Ling Tang  1   2 , Dan-Dan Li  1   2 , Jia-Yu Duan  1   2 , Lei-Ming Sheng  1   2 , Xin Wang  1   3
Affiliations
Review

Resistance to targeted therapy in metastatic colorectal cancer: Current status and new developments

Yuan-Ling Tang et al. World J Gastroenterol. .

Abstract

Colorectal cancer (CRC) is one of the most lethal and common malignancies in the world. Chemotherapy has been the conventional treatment for metastatic CRC (mCRC) patients. However, the effects of chemotherapy have been unsatisfactory. With the advent of targeted therapy, the survival of patients with CRC have been prolonged. Over the past 20 years, targeted therapy for CRC has achieved substantial progress. However, targeted therapy has the same challenge of drug resistance as chemotherapy. Consequently, exploring the resistance mechanism and finding strategies to address the resistance to targeted therapy, along with searching for novel effective regimens, is a constant challenge in the mCRC treatment, and it is also a hot research topic. In this review, we focus on the current status on resistance to existing targeted therapies in mCRC and discuss future developments.

Keywords: Colorectal cancer; New development; Resistance; Targeted treatment.

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Conflict of interest statement

Conflict-of-interest statement: There are no conflicts of interest to report.

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