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Review
. 2023 Mar;23(3):110-116.
doi: 10.1016/j.bjae.2022.12.003. Epub 2023 Jan 23.

Anticoagulation for cardiopulmonary bypass: part one

B Cartwright  1   2 , N Mundell  1
Affiliations
Review

Anticoagulation for cardiopulmonary bypass: part one

B Cartwright et al. BJA Educ. 2023 Mar.
No abstract available

Keywords: anticoagulation; cardiac anaesthesia; cardiopulmonary bypass.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Fig. 1
Interactions between thrombin, antithrombin and heparin. Thrombin (Factor IIa) exosite I: orientates fibrinogen binding and is important for platelet receptor (PAR) recognition; exosite II: binding site for heparin and fibrin, when fibrin is bound this blocks access for heparin. Antithrombin binds at the primary protease site.
Figure 2
Fig. 2
An example of divergence between heparin concentration and measured ACT. ACT, activated clotting time; CPB, cardiopulmonary bypass.
See this image and copyright information in PMC

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